Abstract： This paper introduces Professor ZOU Xu's clinical experience in treating hemorrhagic apoplexy by using Interstitial Space-Triple Energizers Theory based on syndrome differentiation. Professor ZOU Xu believes that "the brain belongs to interstitial space"，and he also thinks the triple energizers belong to the meridian，where qi，blood and water can pass，and that interstitial space belong to the collateral， which is the extension of triple energizers and the structure of nourishing fleshy exterior. All the methods used to treat interstitial space and triple energizers can be used to treat brain diseases. The basic pathogenesis of hemorrhagic apoplexy is deficiency in origin and excess in superficiality，and the attack of fire pathogen is the initiating factor of the disease. Professor ZOU puts forward the treatment of hemorrhagic apoplexy by diffusing triple energizers to subdue fire， and adjusting triple energizers fluid to balance fire and water.