益胃化肠方联合穴位埋线对气虚血瘀型慢性萎缩性胃炎伴肠上皮化生患者胃功能的影响
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R573.3+2

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[基金项目] 金华市科技局计划项目(2020-4-057)


Effect of Yiwei Huachang Prescription Combined with Catgut Embedment in Acupoint on Gastric Function in Patients with Chronic Atrophic Gastritis Complicated with Intestinal Metaplasia of Qi Deficiency and Blood Stasis Type
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    摘要:

    目的:观察益胃化肠方联合穴位埋线对气虚血瘀型慢性萎缩性胃炎伴肠上皮化生患者胃功能的影 响。方法:选取80例气虚血瘀型慢性萎缩性胃炎伴肠化患者,按随机数字表法分为对照组及观察组各40例。 对照组采用穴位埋线治疗,观察组采用穴位埋线联合益胃化肠方治疗。比较2组临床疗效,比较2组治疗前后 内皮功能指标值[降钙素基因相关肽(CGRP)、血管内皮生长因子(VEGF) ]、炎性因子水平[白细胞介素- 17(IL-17)、白细胞介素-10(IL-10) ]、胃功能指标值[胃蛋白酶原(PG)、胃泌素-17(G-17) ]及中医证候 积分的变化。结果:观察组临床疗效总有效率为95.00%,对照组为80.00%,2 组比较,差异有统计学意 义(P<0.05)。治疗后,2组IL-17、IL-10水平均较治疗前下降(P<0.05),观察组IL-17、IL-10水平均低于 对照组(P<0.05)。治疗后,2 组CGRP 指标值均较治疗前升高(P<0.05),VEGF 指标值均较治疗前下 降(P<0.05);观察组CGRP指标值高于对照组(P<0.05),VEGF指标值低于对照组(P<0.05)。治疗后, 2 组PG、G-17指标值均较治疗前升高(P<0.05),观察组PG、G-17指标值均高于对照组(P<0.05)。治疗 后,2组中医证候积分均较治疗前下降(P<0.05),观察组中医证候积分低于对照组(P<0.05)。结论:益胃 化肠方联合穴位埋线治疗气虚血瘀型慢性萎缩性胃炎伴肠上皮化生疗效较好,可缓解临床症状,改善胃功能。

    Abstract:

    Abstract: Objective: To observe the effect of Yiwei Huachang Prescription combined with catgut embedment in acupoint on gastric function in patients with chronic atrophic gastritis complicated with intestinal metaplasia of qi deficiency and blood stasis type. Methods: A total of 80 cases of patients with chronic atrophic gastritis and intestinal metaplasia of qi deficiency and blood stasis type were selected and divided into the control group and the observation group using a random number table method , with 40 cases in each group. The control group was treated with catgut embedment in acupoint, and the observation group was treated with catgut embedment in acupoint combined with Yiwei Huachang Prescription. Compared the clinical efficacy of two groups,and compared the changes in traditional Chinese medicine syndrome scores,endothelial function index values [calcitonin gene related peptide (CGRP),and vascular endothelial growth factor (VEGF)], inflammatory factor levels [interleukin-17 (IL-17), and interleukin-10 (IL-10)],and gastric function index values [gastrin (PG),and gastrin-17 (G-17)] before and after treatment. Results:The total effective rate of clinical efficacy was 95.00% in the observation group, and 80.00% in the control group,the difference being significant (P<0.05). After treatment,the levels of IL-17 and IL-10 in both groups were decreased compared to those before treatment (P<0.05), and the levels of IL-17 and IL-10 in the observation group were lower than those in the control group (P<0.05). After treatment,the CGRP values in both groups were increased compared to those before treatment (P< 0.05), and the VEGF values were decreased compared to those before treatment (P<0.05); the CGRP value in the observation group was higher than that in the control group (P<0.05),and the VEGF value was lower than that in the control group (P<0.05). After treatment, the PG and G-17 values in both groups were increased compared to those before treatment (P<0.05), and the PG and G-17 values in the observation group were higher than those in the control group (P<0.05). After treatment, the traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment (P<0.05),and the traditional Chinese medicine syndrome scores in the observation group were lower than those in the control group (P<0.05). Conclusion: Yiwei Huachang Prescription combined with catgut embedment in acupoint has a good therapeutic effect on chronic atrophic gastritis accompanied by intestinal metaplasia of qi deficiency and blood stasis type, which can alleviate clinical symptoms and improve gastric function.

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郭婷婷,李跃文.益胃化肠方联合穴位埋线对气虚血瘀型慢性萎缩性胃炎伴肠上皮化生患者胃功能的影响[J].新中医,2024,56(17):44-48

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  • 在线发布日期: 2024-09-11
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