Abstract：Objective：To observe the promotion effect of external application with Chuangyu Ointment on wound healing in postoperative with perianal abscess with damp-heat accumulation syndrome. Methods： A total of 70 cases of patients with perianal abscess with damp-heat accumulation syndrome were divided into the treatment group and the control group according to the random number table method， with 35 cases in each group. On the basis of routine dressing changes after surgery，the treatment group received external application with Chuangyu Ointment on the wound， and the control group received external application with Vaseline gauze on the wound. Compared the clinical effect，wound healing time， pain scores， wound secretion scores， anal function， and serum inflammatory index levels between the two groups. Results：After two weeks of treatment，the clinical effect in the treatment group was better than that in the control group， the difference being significant (P＜0.05). The wound healing time in the treatment group was shorter than that in the control group，the difference being significant (P＜0.05). After two weeks of treatment， the scores of pain and wound secretion in both groups were decreased when compared to those on the second day after surgery， and the scores of pain and wound secretion in the treatment group were lower than those in the control group，differences being significant (P＜0.05). After two weeks of treatment， the resting pressure and maximum systolic pressure of the anal canal in both groups were decreased when compared to those before surgery，and the resting pressure and maximum systolic pressure of the anal canal in the treatment group were lower than those in the control group， differences being significant (P＜0.05). After two weeks of treatment， the levels of serum C-reactive protein (CRP)， interleukin-6 (IL-6)， and tumor necrosis factor- α (TNF- α) in the two groups were decreased when compared to those on the second day after surgery， and the levels of CRP， IL-6， and TNF- α in serum in the treatment group were lower than those in the control group， differences being significant (P＜0.05). Conclusion：External application with Chuangyu Ointment can effectively improve the clinical symptoms of postoperative with perianal abscess with damp-heat accumulation syndrome，reduce the levels of inflammatory indicators，improve anal function，and promote wound healing.