Abstract： Objective： To observe the clinical effect of thumb-tack needling combined with Mometasone Furoate Nasal Spray on allergic rhinitis (AR). Methods： A total of 104 cases of AR patients were selected and divided into the control group and the observation group according to the random number table method，with 52 cases in each group. In the control group，four cases were excluded and 48 cases were included. In the observation group，one case was excluded and 51 cases were included. The control group was treated with Mometasone Furoate Nasal Spray， and the observation group was additionally treated with thumb-tack needling based on the treatment of the control group. Both groups were treated for four weeks. The clinical effects，rhinitis symptom scores，and levels of serum inflammatory factors were compared between the two groups. Results：After four weeks of treatment，the total effective rate in the observation group was 94.12%，which was higher than that of 81.25% in the control group，the difference being significant (P＜0.05). The scores of runny nose， sneezing， nasal congestion， and nasal itch in the two groups were decreased when compared with those before treatment，and the scores of the above four rhinitis symptoms in the observation group were lower than those in the control group， differences being significant (P＜0.05). The levels of tumor necrosis factor-α (TNF-α)，interleukin-4 (IL-4)，and interleukin- 13 (IL-13) in serum in the two groups were reduced when compared with those before treatment，and the levels of TNF-α，IL-4，and IL-13 in serum in the observation group were lower than those in the control group， differences being significant (P＜0.05). Conclusion： Thumb-tack needling combined with Mometasone Furoate Nasal Spray has a good clinical effect in the treatment of AR，which can effectively relieve clinical symptoms and inhibit inflammatory responses with good safety.