Abstract： Objective： Based on data mining， to explore the prescription and medication rules and characteristics of Chinese medicine in the treatment of autoimmune liver disease. Methods： The China National Knowledge Infrastructure，Wanfang Database，and VIP Chinese Science and Technology Journal Database were applied for literature retrieval， and the relevant literature was screened and organized according to inclusion and exclusion criteria. Prescription information was entered into the Traditional Chinese Medicine Inheritance Assistance System V3.0 to establish a database. Data mining and analysis were conducted using modules such as "statistical analysis， formula analysis， association rules， and cluster analysis". Results： A total of 139 eligible literature and 139 prescriptions were included， involving 251 Chinese herbal medicines. The top 10 frequency occurrence drugs were Bupleuri Radix， Artemisiae Scopariae Herba， Astragali Radix， Paeoniae Radix Rubra， Atractylodis Macrocephalae Rhizoma， Glycyrrhizae Radix et Rhizoma， Poria， Angelicae Sinensis Radix， Paeoniae Radix Alba， and Curcumae Radix. The medicinal properties were mainly cold and warm， and the medicinal flavour is mainly bitter， sweet， and acrid. The channel entry mainly focused on the liver channel， spleen channel， and lung channel. The top four types of efficacy were supplementing deficiency，clearing heat，promoting urination and percolating dampness，and invigorating blood and dissolving stasis. Association rule analysis obtained 18 high-frequency drug combinations， and the top four were Bupleuri Radix-Glycyrrhizae Radix et Rhizoma，Poria-Atractylodis Macrocephalae Rhizoma，Astragali Radix-Atractylodis Macrocephalae Rhizoma， and Artemisiae Scopariae Herba- Paeoniae Radix Rubra. K-means clustering analysis identified four new core categorized formulas. Conclusion： The prescriptions of traditional Chinese medicine for treating autoimmune liver disease mainly focuses on supplementing deficiency，clearing heat，promoting urination and percolating dampness， and invigorating blood and dissolving stasis. The medication combination and categorized formula analysis reflect the treatment directions of soothing the liver and rectifying qi，boosting qi and fortifying spleen，clearing heat and draining dampness，and invigorating blood and dissolving stasis.