Abstract：Objective：To observe the therapeutic effect of Fengliao Changweikang Capsules combined with standard quadruple therapy in the treatment of Helicobacter pylori (Hp) positive chronic gastritis， as well as its impact on gastrointestinal function and oxidative stress levels. Methods：A prospective study was conducted on 112 patients with Hp positive chronic gastritis. All patients were randomly divided into the combination group and the control group， with 56 cases in each group， using a random number table method. The control group was treated with standard quadruple therapy， and the combination group was treated with Fengliao Changweikang Capsules in combination with the treatment of the control group. Both groups were treated for a total of one month. Compared the Hp conversion negative rate， clinical effects， and incidence of adverse reactions between the two groups， and compared the levels of oxidative stress indicators [serum glutathione peroxidase (GSH-PX)， superoxide dismutase (SOD)， and malondialdehyde (MDA)]， serum inflammatory indicators [interleukin-4 (IL-4)， tumor necrosis factor- α (TNF- α)， interleukin-8 (IL-8)， interleukin-10 (IL-10)， nuclear factor- κB (NF- κB)， and interleukin-6 (IL-6)]，and gastrointestinal function indicators (pepsinogenⅡ，pepsinogenⅠand gastrin) before and after treatment. Results：After treatment，the total effective rate was 96.43% in the combination group，which was higher than the control group's 76.79% (P＜0.05). The Hp conversion negative rate was 85.71% in the combination group， which was higher than the control group's 66.07% (P＜0.05). After treatment， the serum MDA，IL-4，IL-6，IL-8，NF-κB，TNF-α，pepsinogenⅠ，pepsinogenⅡand gastrin levels in the two groups were decreased when compared with those before treatment (P＜0.05)， SOD， GSH-PX and IL-10 levels were increased (P＜0.05). The levels of MDA， IL-4， IL-6， IL-8， NF- κB， TNF- α， pepsinogen Ⅰ ， pepsinogen Ⅱ and gastrin levels in combination group were lower than those in control group (P＜0.05)，and the levels of SOD，GSH-PX and IL-10 in combination group were higher than those in control group (P＜0.05). The incidence of adverse reactions was 8.93% in the combination group，lower than the control group's 23.21% (P＜0.05). Conclusion： The combination of Fengliao Changweikang Capsules and standard quadruple therapy has a significant therapeutic effect on Hp positive chronic gastritis， which can effectively increase the Hp conversion rate， inhibit oxidative stress damage and inflammatory reactions，and improve gastrointestinal function.