Abstract：Objective：To observe the clinical effect of Qingwei Huanglian Pills combined with western medicine in treating senile chronic periodontitis with intense stomach fire syndrome. Methods： A total of 80 elderly patients with chronic periodontitis with intense stomach fire type were divided into two groups according to random number table method，with 40 cases in each group. The reference group was treated with Roxithromycin Capsules and Tinidazole Tablets， and the combination group was given Qingwei Huanglian Pills combined with Roxithromycin Capsules and Tinidazole Tablets. Both groups were treated for two weeks. The traditional Chinese medicine(TCM) syndrome scores，periodontal indexes(scores of plaque indexes， gingival indexes， probe depth and gingival crevicular bleeding indexes) and levels of gingival crevicular fluid inflammatory factors[tumor necrosis factor-α (TNF-α)，interleukin-6 (IL-6) and interleukin- 1β (IL-1β)] before and after treatment were compared between the two groups. The clinical effects and adverse reactions were also compared. Results：After two weeks of treatment，the total effective rate in the combination group was higher than that in the reference group (P＜0.05).The scores of TCM syndromes such as gum swelling and pain，thirst for cold drinks，halitosis and dry stool in both groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the combination group were lower than those in the reference group (P＜0.05). The scores of plaque indexes， gingival indexes， probe depth and gingival crevicular bleeding indexes in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the combination group were lower than those in the reference group (P＜0.05). The levels of TNF-α、IL-6、IL-1β in gingival creval fluid of the two groups were decreased (P＜0.05)， and the levels of above indexes in the combination group were lower than those in the reference group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Qingwei Huanglian Pills combined with western medicine can relieve clinical symptoms and signs on elderly patients with chronic periodontitis with intense stomach fire type，decrease adverse reactions，and have curative effects and good safety.