Abstract： Objective： To discuss the administration rules of Chinese medicine for acute epididymitis based on data mining. Methods：The related literatures on the treatment of acute epididymitis with Chinese medicine published by China National Knowledge Infrastructure (CNKI) and Wanfang Data Knowledge Service Platform (WF) from the establishment of database to August 1st， 2023 were searched. The database of Chinese medicine prescriptions for oral administration and external application was established respectively，and the use frequency，curative effects，four qi，five flavors and channel entry of Chinese medicinals were counted by using Traditional Chinese Medicine Inheritance Assistant Platform (V3.5)，and association rules and cluster analysis were carried out. Results：After screening，a total of 95 articles were obtained， including 74 on oral administration of Chinese medicine and 21 on external application with Chinese medicine. A total of 102 prescriptions， including 63 Chinese medicine prescriptions for oral administration and 39 for external application. The top five Chinese medicinals in frequency of oral administration were Glycyrrhizae Radix et Rhizoma， Angelicae Sinensis Radix， Bupleuri Radix， Alismatis Rhizoma and Chinese Gentian and in the frequency of external application were Rhei Radix et Rhizoma， Phellodendri Chinensis Cortex， Trichosanthis Radix， Glycyrrhizae Radix et Rhizoma and Angelicae Dahuricae Radix. The curative effects of Chinese medicinals for internal use are more common in clearing heat，activating blood and resolving stasis，and inducing diuresis to drain dampness，and those of Chinese medicinals for external application are more common in clearing heat，activating blood and resolving stasis， and purgation. The four qi of Chinese medicinals for oral administration and external application is mainly cold，followed by warm；their flavor is mainly bitter，followed by sweet or pungent. The top three channel entries of Chinese medicinals for oral administration are the liver， lung and heart， and those of Chinese medicinals for external application are the spleen，liver and lung. Through the analysis of association rules， 30 commonly used combinations and eight core association rules were obtained in terms of Chinese medicinals for oral administration；six commonly used combinations and seven core association rules were obtained in terms of Chinese medicinals for application. According to the cluster analysis， four core combinations of Chinese medicinals were obtained for the oral administration and external application， respectively. Conclusion： Chinese medicine for acute epididymitis， whether oral administration and external application，emphasizes heat-clearing and detoxifying，and blood activating and stasis resolving， and the prescriptions mainly consist of bitter， cold and heat-clearing Chinese medicinals. The core combinations of Chinese medicinals for oral administration are given respectively to treat the pathogenesis of damp-heat accumulation， and excessive heat and toxin obstruction in the early stage of acute epididymitis， and blood stasis blocking collaterals and blood stasis-toxin binding in the later stage by clearing heat and inducing diuresis，activating blood and detoxifying，activating blood and resolving stasis， clearing heat and detoxifying，and softening hardness and dissipating masses，respectively. The methods of clearing heat and removing dampness，promoting blood circulation and detoxification，promoting blood circulation and removing blood stasis，clearing heat and detoxifying，and softening hardness and resolving masses are used respectively. The core combinations of Chinese medicinals for external application are often for heat-clearing and dampness-eliminating， heat-clearing and detoxifying combined with bloodactivating and stasis-resolving to improve local symptoms.