Abstract： Objective： To study the relationship between pathological characteristics and Chinese medicine constitutions of colorectal polyp (CP) patients among permanent residents in Wenzhou. Methods： A total of 1 142 permanent residents who voluntarily underwent CP screening at Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University from May 2020 to July 2022 were selected； CP-positive patients were diagnosed through fecal occult blood test and colonoscopy examination. Clinical data of patients were collected and their Chinese medicine constitutions were determined to analyze the correlation between their pathological characteristics and Chinese medicine constitution. Results：The fecal occult blood test on 1 142 permanent residents showed that 469 permanent residents were found CP-positive， including 167 weak positive cases and 302 positive cases. A total of 400 cases of CP were diagnosed through colonoscopy and pathological diagnosis，with a CP incidence rate of 35.03%. Chinese Medicine constitution analysis showed that among 400 CP patients， the damp-heat constitution was the most common， accounting for 24.50%； next were the phlegm-damp constitution and qi deficiency constitution， accounting for 23.00% and 19.00% respectively； the neutral constitution was the least，accounting for 9.00%. Among 400 CP patients，there were 202 cases under 60 years old， and 198 cases were 60 years old or above. Among CP patients under 60 years old， the phlegm-damp constitution was the most common， followed by the damp-heat constitution， and the proportion of phlegm-damp constitution and the damp-heat constitution was higher than that of CP patients who were 60 years old or above， with differences being significant (P＜0.05). The proportion of qi deficiency constitution was the highest among CP patients who were aged 60 years or above，which was higher than that of CP patients aged under 60 years old， with the difference being significant (P＜0.05). There was significant difference in the location of lesions among patients with qi deficiency constitutions (P＜0.05). Among patients with CP lesions with a diameter greater than one centimeter， the proportion of qi deficiency constitution was the highest，accounting for 32.61%，which was higher than that of CP patients with lesions with a diameter equal to or smaller than one centimeter (P＜0.05)； among CP patients with lesion diameter equal to or smaller than one centimeter，damp-heat constitution was the most common， accounting for 28.70%，and the proportion of damp-heat constitution was higher than that of CP patients with lesion diameter greater than one centimeter (P＜0.05). Among patients with adenomatous polyps，the proportion of qi deficiency constitution was the highest， accounting for 24.18%， and the proportion of qi deficiency constitution was higher than that of patients with inflammatory or proliferative polyps，with the difference being significant (P＜0.05). Among patients with inflammatory or proliferative polyps， dampheat constitution and phlegm-damp constitution were the most common， accounting for 30.77% and 28.21% respectively， and the proportion of damp-heat constitution and phlegm-damp constitution was higher than that of patients with adenomatous polyps， with the differences being significant (P＜0.05). Conclusion：The CP screening among permanent residents in Wenzhou showed that the incidence rate of CP was 35.03%. Among CP patients， damp-heat constitution， phlegm-damp constitution， and qi deficiency constitution accounted for the largest proportion， and the age， polyp size， and pathological types of CP patients had a certain relationship with damp-heat constitution， phlegm-damp constitution， and qi deficiency constitution.