Abstract： Objective： To observe the clinical effect of the combination use of Peiyuan Guben Tongbi Prescription and Mecobalamin Tablets on chemotherapy-induced peripheral neuropathy (CIPN) with syndrome of qi deficiency and blood stasis. Methods： A total of 98 CIPN patients with syndrome of qi deficiency and blood stasis were divided into the treatment group and the control group according to the random number table method， with 49 cases in each group. The control group was treated with Mecobalamin Tablets， and the treatment group was treated with Peiyuan Guben Tongbi Prescrition combined with Mecobalamin Tablets. The two groups were treated for four weeks. The clinical effects，and the traditional Chinese medicine (TCM) syndrome scores， peripheral neurotoxicity grading， and nerve conduction velocity and arterial blood flow velocity of lower limbs were compared before and after treatment between the two groups. Results：The total effective rate was 89.80% in the treatment group，higher than that of 73.47% in the control group (P＜0.05). After treatment， the peripheral neurotoxicity grading and TCM syndrome scores in the two groups were reduced when compared with those before treatment (P＜ 0.05)， and the peripheral neurotoxicity grading and TCM syndrome scores in the treatment group were lower than those in the control group (P＜0.05). After treatment， the sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) of nervus peroneus communis and median nerve， and the blood flow velocity of popliteal artery and femoral artery of lower limbs in the two groups were faster than those before treatment (P＜0.05)，the MCV and SCV of nervus peroneus communis and median nerve， and the blood flow velocity of popliteal artery and femoral artery of lower limbs in the treatment group were faster than those in the control group (P＜0.05). Conclusion：The combination use of Peiyuan Guben Tongbi Prescription and Mecobalamin Tablets has a definite curative effect on CIPN with syndrome of qi deficiency and blood stasis， which can reduce the peripheral nerve injury， and accelerate the nerve conduction velocity and arterial blood flow velocity of lower limbs.