Abstract： Objective： To observe the clinical effect of the combination use of modified Danggui Shaoyao Powder and Chinese medicine enema on chronic pelvic inflammatory disease and its effect on inflammatory factors. Methods：A total of 90 patients with chronic pelvic inflammatory disease were divided into the observation group and the control group according to the random number table method ， with 45 cases in each group. The control group was treated with Levofloxacin and Metronidazole， and the observation group was additionally treated with modified Danggui Shaoyao Powder combined with Chinese medicine enema based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores，scores of 36-item health survey (SF-36) and levels of serum inflammatory factors [Creactive protein (CRP)， interleukin (IL) -2， IL-6 and tumor necrosis factor- α (TNF- α)] were compared before and after treatment between the two groups；the clinical effects，recurrence rates and incidence of adverse reactions in the two groups were evaluated. Results：After treatment，the total effective rate was 97.78% in the observation group， higher than that of 71.11% in the control group (P＜0.05). After treatment， the TCM syndrome scores and the levels of serum CRP， IL-2， IL-6 and TNF- α in the two groups were decreased when compared with those before treatment (P＜0.05)， and the SF-36 scores were increased (P＜0.05)； after treatment， the TCM syndrome scores and the levels of serum inflammatory factors in the observation group were lower than those in the control group (P＜0.05)，and the SF-36 scores was higher than that in the control group (P＜0.05). The incidence of adverse reactions and the recurrence rate were respectively 4.44% and 3.12% in the observation group and 17.78% and 21.74% in the control group， the difference being significant (P＜0.05). Conclusion： The combination use of modified Danggui Shaoyao Powder and Chinese medicine enema has a significant clinical effect on chronic pelvic inflammatory disease， which can effectively mitigate the inflammatory responses of patients， enhance the quality of life and reduce the recurrence with great safety.