Abstract： Objective： To observe the clinical effect of White Ointment combined with western medicine on acute gouty arthritis (GA) of damp-heat accumulation type and its safety. Methods：A total of 64 cases of patients with acute GA with damp-heat accumulation type were selected and divided into the treatment group and the control group by random number table method，with 32 cases in each group. Two cases were excluded in each group during the study. The control group was treated with western medicine (Diclofenac Sodium，Sodium Bicarbonate，Omeprazole)，and the treatment group was combined with White Ointment based on the treatment of the control group. Both groups were treated for two weeks continuously. The clinical effects， symptom scores and inflammatory indexes [white blood cell count (WBC)，erythrocyte sedimentation rate (ESR)，C-reactive protein (CRP)] were compared between the two groups，and the safety of treatment was evaluated. Results：After two-week treatment，the cure rate in the treatment group was 50.00%， higher than that of 23.33% in the control group (P＜0.05). After two- week treatment，the scores of joint swelling，pain and limited activity in both groups were decreased when compared with those before treatment (P＜0.05)， and the above three symptom scores in the treatment group were lower than those in the control group (P＜0.05). After two-week treatment， levels of WBC， ESR and CRP in both groups were decreased when compared with those before treatment (P＜0.05)，and levels of WBC and ESR in the treatment group were lower than those in the control group (P＜0.05). There was no significant difference in levels of CRP between the two groups (P＞0.05). The incidence of adverse reactions was 13.33% in the treatment group and 16.67% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion： White Ointment combined with western medicine has a great therapeutic effect on acute GA of damp-heat accumulation type， which can relieve the symptoms of joint pain， swelling and limited activity and reduce the levels of inflammation indexes， with great safety.