Abstract：Objective：To observe the clinical effect of the combination use of iontophoresis of Zengshi Decoction and Tropicamide Eye Drops on pseudomyopia in youngsters. Methods：A total of 240 youngsters with pseudomyopia were selected and divided into the control group and the treatment group according to the random number table method， with 120 cases in each group. The control group was treated with Tropicamide Eye Drops， and the treatment group was additionally treated with iontophoresis of Zengshi Decoction based on the treatment of the control group. After one month of treatment，the clinical effects， traditional Chinese medicine (TCM) syndrome scores， visual acuity indexes (lens thickness， anterior chamber depth and uncorrected visual acuity)， best corrected visual acuity， astigmatism， and diopter were compared between the two groups. Results： The total effective rate was 95.00% in the treatment group and 75.00% in the control group， the difference being significant (P＜0.05). After treatment， the TCM syndrome scores of blurred vision，dizziness and headache，upset，soreness and weakness of waist and knees in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the treatment group were lower than those in the control group (P＜0.05). After treatment，the uncorrected visual acuity in the two groups was increased when compared with that before treatment (P＜0.05)，and the increase rate in the treatment group was higher than that in the control group (P＜0.05)； the lens thickness and anterior chamber depth in the two groups were decreased than those before treatment (P＜0.05)，and the two visual acuity indexes in the treatment group was less than that in the control group (P＜0.05). After treatment， the diopter after mydriasis in the two groups was elevated when compared with that before treatment (P＜0.05)， and the diopter after mydriasis in the treatment group was higher than that in the control group (P＜0.05)；there was no significant difference being found in the comparisons of astigmatism and best corrected visual acuity between the two groups before and after treatment and between the two groups after treatment (P＞0.05). Conclusion： The combination use of iontophoresis of Zengshi Decoction and Tropicamide Eye Drops can improve the TCM syndromes，related visual acuity index and the diopter after mydriasis of youngsters with pseudomyopia and enhance the clinical effect.