Abstract： Objective： To systematically evaluate the clinical effects and safety of Chinese medicine periodic therapy combined with ovulation protocol induction in the treatment of infertility caused by polycystic ovary syndrome (PCOS). Methods： Randomized controlled trials of Chinese medicine periodic therapy for treating infertility caused by PCOS were included in the study after the search at PubMed， Embase， Web of Science，the Cochrane Library，Chinese BioMedical Literature Database (CBM)，China National Knowledge Infrastructure (CNKI)， Wanfang Database， and VIP Database， with a search period from the establishment of these databases to February 2024. Two researchers independently screened literature and collected data according to inclusion and exclusion criteria. Meta analysis was conducted using RevMan5.4 software. Results： Finally， 15 studies were included， involving 1 171 patients， including 594 cases in the treatment group and 577 cases in the control group. The Meta-analysis results showed that， compared with the control group， the treatment group had increases in pregnancy rate [RR=1.80， 95%CI (1.58， 2.04)， P＜0.000 01]， ovulation rate [RR=1.10， 95%CI (1.06， 1.14)， P＜0.000 01]， total effective rate [RR=1.25， 95%CI= (1.15， 1.37)， P＜0.000 01]， and endometrial thickness [MD=1.12， 95%CI (0.94，1.29)，P＜0.000 01]，and decreases in androgen[MD=-0.39，95%CI (-0.52，-0.26)，P＜ 0.000 01]， luteinizing hormone [MD=-1.49， 95%CI (-1.93， -1.05)， P＜0.000 01]， the incidence of ovarian hyperstimulation [RR=0.25，95%CI (0.08，0.79)，P=0.02]，and the incidence of adverse reactions [RR=0.36，95%CI (0.19，0.67)，P=0.001]. Conclusion：Chinese medicine periodic therapy combined with ovulation induction protocol in the treatment of infertility caused by PCOS has better curative effects than simple treatment scheme of ovulation induction protocol， which can promote fertility， regulate hormone levels，and has high safety.