枣仁安神方联合氢溴酸伏硫西汀片治疗心肝血虚型抑郁症临床研究
DOI:
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R749.4;R277.7

基金项目:


Clinical Study on Zaoren Anshen Prescription and Vortioxetine Hydrobromide Tablets for Depression of Heart-Liver Blood Deficiency Type
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察枣仁安神方联合氢溴酸伏硫西汀片治疗心肝血虚型抑郁症患者的临床疗效。方法:回 顾性分析衢州市第三医院收治的78例心肝血虚型抑郁症患者的临床资料,依据治疗方法分为对照组、观察组 各39例。对照组予氢溴酸伏硫西汀片治疗,观察组予枣仁安神方加减联合氢溴酸伏硫西汀片治疗。2组均治疗 8周。治疗前、治疗8周后评价2组患者的中医证候评分、焦虑自评量表(SAS) 评分、抑郁自评量表(SDS) 评分、睡眠质量[匹兹堡睡眠质量指数量表(PSQI) 评分],检测γ-氨基丁酸(GABA)、5-羟色胺(5-HT) 水平。比较2组治疗8周内的不良反应发生率与治疗8周后的临床疗效。结果:治疗8周后,观察组总有效率高 于对照组(P<0.05)。2组中医证候积分均较治疗前下降(P<0.05)。观察组中医证候积分低于对照组(P< 0.05)。2组SDS评分、SAS评分均较治疗前下降(P<0.05)。观察组SDS评分、SAS评分均低于对照组(P< 0.05)。2组PSQI评分均较治疗前下降(P<0.05)。观察组PSQI评分低于对照组(P<0.05)。2组GABA、5-HT 水平均较治疗前升高(P<0.05)。观察组GABA、5-HT水平均高于对照组(P<0.05)。对照组不良反应发生率 12.82% (5/39),高于观察组(2.56%,1/39),但差异无统计学意义(P>0.05)。结论:枣仁安神方加减联合 氢溴酸伏硫西汀片治疗心肝血虚型抑郁症患者临床疗效显著,可有效缓解症状,减轻患者的焦虑、抑郁程度, 还能改善睡眠质量,且安全性高。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Zaoren Anshen Prescription combined with Vortioxetine Hydrobromide Tablets in the treatment of depression of the heart-liver blood deficiency type. Methods:A retrospective analysis was conducted on the clinical data of 78 patients with depression of the heart-liver blood deficiency type at the Third Hospital of Quzhou. According to the treatment method,they were divided into the control group and the observation group, with 39 cases in each group. The control group was treated with Vortioxetine Hydrobromide Tablets, and the observation group was treated with modified Zaoren Anshen Prescription and Vortioxetine Hydrobromide Tablets. Both groups were treated for eight weeks. The traditional Chinese medicine (TCM) syndrome scores, and the scores of Self-Rating Anxiety Scale (SAS),Self-Rating Depression Scale (SDS),and Pittsburgh Sleep Quality Index (PSQI) were evaluated,the levels of γ-aminobutyric acid (GABA) and serotonin (5-HT) were detected before and after eight weeks of treatment. The incidence of adverse reactions within eight weeks of treatment and the clinical effects after eight weeks of treatment were compared between the two groups. Results: After eight weeks of treatment, the total effective rate in the observation group was higher than that in the control group (P<0.05). The TCM syndrome scores in the two groups were decreased when compared with those before treatment (P<0.05). The TCM syndrome score in the observation group was lower than that in the control group (P<0.05). The SDS and SAS scores in the two groups were declined when compared with those before treatment (P<0.05). The SDS and SAS scores in the observation group were lower than those in the control group (P<0.05). Both groups showed a decrease in PSQI scores when compared with those before treatment (P<0.05). The PSQI score in the observation group was lower than that in the control group (P<0.05). The levels of GABA and 5-HT in the two groups were increased when compared with those before treatment (P<0.05). The levels of GABA and 5-HT in the observation group were higher than those in the control group (P<0.05). The incidence of adverse reactions in the control group was 12.82% (5/39),which was higher than that in the observation group (2.56%,1/39),but the difference was not statistically significant (P>0.05). Conclusion:The combination of modified Zaoren Anshen Prescription and Vortioxetine Hydrobromide Tablets has significant clinical effects in treating depression patients of the heartliver blood deficiency type. It can effectively alleviate symptoms, reduce patients' anxiety and depression levels,and improve sleep quality,with high safety.

    参考文献
    相似文献
    引证文献
引用本文

徐鹏昊,王艳.枣仁安神方联合氢溴酸伏硫西汀片治疗心肝血虚型抑郁症临床研究[J].新中医,2024,56(23):35-39

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2024-12-19
  • 出版日期:
文章二维码