Abstract： Objective： To observe the clinical effect of Buqi Decoction combined with Tiotropium Bromide Powder for inhalation on chronic obstructive pulmonary disease (COPD) at stable stage of lungspleen qi deficiency type. Methods：A total of 80 cases of COPD patients at stable stage of lung-spleen qi deficiency type were divided into the control group and the treatment group using a random number table method， with 40 patients in each group. Five cases fell out of the treatment group， with one case excluded；six cases fell out of the control group. In the two groups，there were 34 cases completing the study. The control group received Tiotropium Bromide Powder for inhalation treatment， and the treatment group was treated with Buqi Decoction in addition to the treatment of the control group. Both groups were treated for three months. After treatment，compared the clinical efficacy between the two groups. Before and after treatment， compared the traditional Chinese medicine syndrome scores， dyspnea grading in modified version of the UK Medical Research Council Respiratory Scale (mMRC)，COPD Assessment Test (CAT) scores of COPD patients，and lung function between the two groups. Results：After treatment，the total effective rate was 94.12% in the treatment group，which was higher than that of 76.47% in the control group (P＜0.05). After treatment， the traditional Chinese medicine syndrome scores， CAT scores in both groups were decreased when compared with those before treatment (P＜0.05)； the mMRC dyspnea grading in the treatment group was decreased when compared with that before treatment (P＜0.05)； the traditional Chinese medicine syndrome score， CAT score， and mMRC dyspnea grading in the treatment group were lower than those in the control group (P＜0.05). After treatment，the forced expiratory volume in one second (FEV1)， forced vital capacity (FVC)， and FEV1/FVC in both groups were increased when compared with those before treatment (P＜0.05)； the FEV1， FVC， and FEV1/FVC in the treatment group were all higher than those in the control group (P＜0.05). Conclusion： Buqi Decoction combined with Tiotropium Bromide Powder for Inhalation for COPD patients at stable stage of lung-spleen qi deficiency type can relieve clinical symptoms more effectively，improve lung function，and achieve significant clinical efficacy.