Abstract： Objective： To observe the situation of Chinese medicine abdominal diagnosis in sepsis patients， and to summarize the rules to provide preliminary ideas and clinical basis for the application of Chinese medicine abdominal diagnosis in sepsis patients. Methods： The criteria for the yin-yang classification of Chinese medicine abdominal diagnosis and six key signs of abdominal diagnosis (abdominal shape， abdominal tenderness， abdominal temperature， abdominal strength， bowel sounds， abdominal circumference) were summarized and organized through literature review. Then， a total of 52 sepsis patients were included and divided into the abdominal yin syndrome group and the abdominal yang syndrome group based on abdominal diagnosis information and stool condition. The correlation between abdominal yin-yang classification and abdominal diagnosis information and stool was compared， and the Gastrointestinal Failure (GIF) scores，Sequential Organ Failure Assessment (SOFA) scores，white blood cell (WBC)， C-reactive protein (CRP)， and procalcitonin (PCT) were compared. Results： There was no correlation between the abdominal yin-yang classification and gender，age，abdominal shape，abdominal tenderness， and stool (P＞0.05)； there is a positive correlation between abdominal temperature and abdominal force (P＜0.05). The GIF scores and abdominal circumference in the abdominal yang syndrome group were higher than those in the abdominal yin syndrome group (P＜0.05). The WBC count in the abdominal yin syndrome group was slightly higher than that in the abdominal yang syndrome group，and the SOFA score in the abdominal yang syndrome group was higher than that in the abdominal yin syndrome group， but there was no significant difference (P＞0.05). The levels of CRP and PCT in patients with abdominal yang syndrome were higher than those in the abdominal yin syndrome group (P＜0.05). Conclusion：Chinese medicine abdominal diagnosis can preliminarily predict the critical condition and overall prognosis of sepsis patients.