Abstract： Objective： To observe the clinical effect of Shuyao Huoxue Prescription combined with selective nerve root block on lumbar disc herniation with qi stagnation and blood stasis type. Methods： A total of 108 cases of patients with lumbar disc herniation with qi stagnation and blood stasis type were selected and divided into the control group and the trial group according to the random number table method， with 54 cases in each group. Two cases were excluded from each group， with a final total of 52 cases per group.The control group was treated with selective nerve root block，and the trial group was treated with Shuyao Huoxue Prescription on top of the control group's treatment.Both groups were treated for two weeks. The clinical efficacy，traditional Chinese medicine syndrome scores，visual Analogue Scale (VAS) scores， Qswestry Disability Index (ODI) scores， and levels of inflammatory factors [tumor necrosis factor- α (TNF- α)； interleukin (IL) -6， IL-1β] were compared between the two groups. Results： After treatment， the total effective rate in the trial group 94.23% was higher than that 80.77% in the control group (P＜0.05). Traditional Chinese medicine syndrome scores， VAS scores， and ODI scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores in the trial group were lower than those in the control group (P＜0.05). The levels of TNF- α，IL-6，and IL-1β in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels in the trial group were lower than those in the control group (P＜0.05). Conclusion：Shuyao Huoxue Prescription combined with selective nerve root block in the treatment of lumbar disc herniation can enhance clinical efficacy， improve traditional Chinese medicine syndromes and lumbar function， relieve pain， and inhibit inflammatory response.