Abstract： This article elaborates on the etiological concept of toxin in Chinese medicine， the connotation of the pathogenesis of toxin pathogens inducing diseases and its prevention and treatment ideas. Based on these，combined with the modern pathogenesis of cardiovascular diseases，it focuses on the pathogenesis of toxin pathogens inducing diseases in cardiovascular diseases： the pathological products produced by neuroendocrine activation ， metabolic disorders ， and inflammatory reactions in the pathogenesis of cardiovascular diseases， such as oxygen free radicals， vasoactive substances， inflammatory factors，and so on，which are equivalent to endogenous toxin pathogens；the reconstruction of cardiac blood vessels and its associated damage to target organs are comparable to toxin damaging the heart vessels (including toxin damaging the heart and toxin damaging the vessels). Based on this pathogenesis theory， the prevention and treatment of toxin pathogens can be integrated into the entire process of preventing and treating common cardiovascular diseases such as hypertension，coronary heart disease，and heart failure in clinical practice. Following the principles of "preventing diseases before toxins occur，eliminating toxins of existing diseases，and controlling the development of existing disease due to excessive toxins"， various methods of preventing and eliminating toxins can be combined on the basis of syndrome differentiation and treatment to reduce and clear the accumulative toxin pathogens and decrease their harm.