Abstract：Objective：To observe the curative effect of modified Buyang Huanwu Decoction on poststroke sequela of qi deficiency and blood stasis type based on the routine therapy in modern medicine and acupuncture. Methods：A total of 82 cases with post-stroke sequela of qi deficiency and blood stasis type were randomly divided into the control group and the treatment group，with 41 cases in each group. Both groups were treated with routine therapy and acupuncture， and the treatment group was additionally treated with modified Buyang Huanwu Decoction. Both groups were treated for four courses of treatment. Before and after four courses of treatment，the traditional Chinese medicine (TCM) syndrome scores，and the score of National Institutes of Health Stroke Scale (NIHSS)，Modified Barthel Index，and World Health Organization Quality of Life Brief Scale (WHOQOL-BREF) were evaluated；the hemorheology indexes (red cell aggregation， plasma viscosity， whole blood high-shear viscosity and whole blood low-shear viscosity)，and the inflammatory factors [tumor necrosis factor- α (TNF- α) and interleukin-6 (IL-6 )] were detected. After four courses of treatment，the clinical effects in the two groups were evaluated. Results： After four courses of treatment，the total effective rate in the treatment group was higher than that in the control group (P＜0.05). The TCM syndrome scores in the two groups were lower than those before treatment (P＜0.05)， and the TCM syndrome score in the treatment group was lower than that in the control group (P＜0.05). The red cell aggregation index， plasma viscosity， whole blood high-shear viscosity and whole blood low-shear viscosity in the two groups were dwindled when compared with those before treatment (P＜0.05)， and the above four indexes in the treatment group were lower than those in the control group (P＜0.05). The levels of TNF-α and IL-6 in the two groups were reduced when compared with those before treatment (P＜0.05)， and the levels of TNF- α and IL-6 in the treatment group were lower than those in the control group (P＜0.05). The NIHSS scores in the two groups were decreased when compared with those before treatment， and the scores of Modified Barthel Index and WHOQOL-BREF were elevated when compared with those before treatment， differences being significant (P＜0.05). The NIHSS score in the treatment group was lower than that in the control group，and the scores of Modified Barthel Index and WHOQOL-BREF were higher than those in the control group， differences being significant (P＜0.05). Conclusion： The additional administration of modified Buyang Huanwu Decoction based on the routine therapy in modern medicine and acupuncture has a significant curative effect on poststroke sequela of qi deficiency and blood stasis type，which can not only mitigate the clinical symptoms of patients， improve the blood circulation and reduce the inflammatory responses， but also enhance the activities of daily living and quality of life with great safety.