Abstract： Objective： To observe the clinical effect of Xinkang Prescription Ointment on chronic heart failure. Methods：A total of 104 cases of patients with chronic heart failure were randomly divided into the ointment group and the control group using a random number table method，with 52 cases in each group. Five subjects withdrew from the study due to personal reasons such as fail to follow-up (one in the ointment group and four in the control group). The actual number of completed cases was 99 ， with 51 cases in the ointment group and 48 cases in the control group. The control group received conventional western medicine treatment for heart failure， and the ointment group received additional treatment with Xinkang Poescription Ointment based on the control group's treatment. After 12 weeks of treatment， the levels of N-terminal pro-B type natriuretic peptide (NT proBNP)， left ventricular ejection fraction (LVEF)， 6-minute walk test (6MWT)， and Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores before and after treatment as well as the clinical effects were compared between the two groups. Results：The total effective rate was 92.2% in the ointment group，and 75.0% in the control group，the difference being significant (P＜0.05). After treatment， the levels of NT proBNP in both groups were decreased when compared with those before treatment (P＜0.05)， and levels of LVEF were increased when compared with those before treatment (P＜0.05)； the NT proBNP level in the ointment group was lower than that in the control group (P＜0.05)，and the LVEF was higher than that in the control group (P＜ 0.05). After treatment，the 6MWT distance in both groups was increased when compared with that before treatment (P＜0.05)，and the MLHFQ scores were decreased when compared with those before treatment (P＜0.05)；the 6MWT distance in the ointment group was greater than that in the control group (P＜0.05)， and the MLHFQ score was lower than that in the control group (P＜0.05). Conclusion：Xinkang Prescription Ointment can improve clinical efficacy，enhance heart function，and improve quality of life in patients with chronic heart failure.