Abstract：Objective：To observe the clinical effect of the therapy of Tongyu Huatan Xifeng Decoction combined with thrombolysis on acute cerebral infarction (ACI) and its effects on serum oxidative stress indexes. Methods：A total of 82 ACI patients were divided into two groups according to the random number table method，with 41 cases in each group. The control group was treated with intravenous thrombolysis， and the treatment group was additionally treated with Tongyu Huatan Xifeng Decoction based on the treatment plan of the control group. The changes of traditional Chinese medicine syndrome scores， the scores of National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI) and the oxidative stress indexes were compared before and after treatment between the two groups. The clinical effects and incidence of adverse reactions in the two groups were observed. Results：After treatment，the traditional Chinese medicine syndrome scores of each item in the two groups were reduced， and the scores of hemiplegia，skewed mouth and tongue，hemianesthesia and dizziness in the treatment group were lower than those in the control group， differences being significant (P＜0.05). After treatment， the BI scores in the two groups were elevated，and the NIHSS scores were reduced；the BI score in the treatment group was higher than that in the control group，and the NIHSS score was lower than that in the control group， differences being significant (P＜0.05). After treatment， the levels of malondialdehyde (MDA) in the two groups were down-regulated， and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were elevated. The MDA level in the treatment group was lower than that in the control group， and the levels of SOD and GSH-Px were higher than those in the control group， differences being significant (P＜0.05). The total clinical effective rate was 97.56% in the treatment group and 80.49% in the control group，the difference being significant (P＜0.05). The incidence of adverse reactions was 4.88% in the treatment group and 12.20% in the control group， there being no significance in the difference (P＞ 0.05). Conclusion： The therapy of Tongyu Huatan Xifeng Decoction combined with thrombolysis has a significant clinical effect on ACI， which could improve the symptoms of traditional Chinese medicine， promote the recovery of nerve function，and improve the ability of self-care with a positive impact on the serum oxidative stress indexes. The incidence of adverse reactions during treatment is relatively low with good safety.