Abstract:Objective:To analyze the medication rules of Chinese herbal compounds for treating vertigo by data mining techniques based on the patent search and analysis platform of the China National Intellectual Property Administration. Methods: Chinese herbal compounds for treating vertigo were collected from the patent search and analysis platform of the China National Intellectual Property Administration.The usage,natures and flavors,meridian entries,and efficacy of the Chinese medicinals were statistically analyzed using Excel 2021.Association rule analysis and hierarchical cluster analysis were performed using R software. A complex co-occurrence network of Chinese medicinals was constructed using Cytoscape software, and key subnetworks were identified with the MCODE plugin. Results:A total of 57 Chinese herbal compounds were included,comprising 574 different Chinese medicinals with a total usage frequency of 4 660 times.Among these,40 Chinese medicinals had a usage frequency of 0 times or more, with Gastrodiae Rhizoma being the most frequently used. Analysis of the natures, flavors, meridian entries, and efficacy of the Chinese medicinals showed that warm, cold and neutral properties were predominant, with sweet, bitter,and acrid flavors being the most common.The Chinese medicinals mainly targeted the liver,spleen,and heart meridians, with deficiency-supplementing herbs being the most frequently used. Association rule analysis revealed that the top four triplet medicinals with the highest lift were Glycyrrhizae Radix et Rhizoma-Pinelliae Rhizoma-Citri Reticulatae Pericarpium, Poria-Pinelliae Rhizoma-Citri Reticulatae Pericarpium, Atractylodis Macrocephalae Rhizoma-Pinelliae Rhizoma-Citri Reticulatae Pericarpium, and Gastrodiae Rhizoma-Citri Reticulatae Pericarpium- Pinelliae Rhizoma. Five drug combinations were obtained by cluster analysis, namely Atractylodis Macrocephalae Rhizoma-Poria-Alismatis Rhizoma-Citri Reticulatae Pericarpium-Pinelliae Rhizoma-Glycyrrhizae Radix et Rhizoma, Uncariae Ramulus cum Uncis-Gastrodiae Rhizoma, Acori Tatarinowii Rhizoma-Salviae Miltiorrhizae Radix et Rhizoma-Puerariae Lobatae Radix-Chuanxiong Rhizoma, Codonopsis Radix-Astragali Radix-Angelicae Sinensis Radix, and Achyranthis Bidentatae Radix-Ostreae Concha-Bupleuri Radix-Rehmanniae Radix-Chrysanthemi Flos- Paeoniae Radix Alba-Lycii Fructus-Prunellae Spica-Rehmanniae Radix Praeparata-Corni Fructus.The co-occurrence network analysis indicated that Gastrodiae Rhizoma, Glycyrrhizae Radix et Rhizoma, Poria, Atractylodis Macrocephalae Rhizoma, Chuanxiong Rhizoma, and Pinelliae Rhizoma were the core herbs with high connectivity. The key subnetwork analysis of non-high-frequency herbs identified nine herb combinations with strong association strength.Conclusion:The treatment of vertigo should focus on tonifying the spleen and kidney,calming the liver and extinguishing wind,and draining dampness and invigorating blood.Emphasis should be placed on the compatibility of key Chinese herbs such as Gastrodiae Rhizoma,Glycyrrhizae Radix et Rhizoma,Poria,Atractylodis Macrocephalae Rhizoma,and Pinelliae Rhizoma.