Abstract： Objective： To observe the clinical effect of Jieyu Anshen Capsules combined with Risperidone on schizophrenia of binding constraint of liver qi type. Methods： A total of 90 cases of patients with schizophrenia of binding constraint of liver qi type treated at the Third Hospital of Quzhou from January 2019 to December 202 were selected and divided into the control group and the observation group according to the random number table method， with 45 cases in each group. Both groups were given psychotherapy. The control group was treated with Risperidone Orally Disintegrating Tablets， and the observation group was treated with Jieyu Anshen Capsules combined with Risperidone Orally Disintegrating Tablets. Both groups were treated for eight weeks. Traditional Chinese medicine （TCM） syndrome scores， Positive and Negative Syndrome Scale （PANSS） scores， and Automated Computerized Cognitive Test （ACCT） scores were evaluated before and after treatment； the indexes of blood glucose[fasting blood glucose （FBG），Two-hour fasting insulin （FINS）] and blood lipids [ total cholesterol （TC），triglycerides （TG）] were measured； the incidence of adverse reactions within the first week of treatment was observed. Clinical effects were compared between the two groups. Results：After eight weeks of treatment，the total effective rate in the observation group was higher than that in the control group （P＜0.05）. TCM syndrome scores in the two groups were reduced when compared with those before treatment （P＜0.05），with the observation group scoring lower than the control group （P＜ 0.05）. PANSS scores in the two groups were decreased when compared with those before treatment，and ACCT scores were increased when compared with those before treatment， differences being significant （P＜0.05）. The observation group had lower PANSS score and higher ACCT score compared to the control group，differences being significant （P＜ 0.05）. The levels of FBG，two-hour FINS，TC，and TG in the control group were increased when compared with those before treatment （P＜0.05）； the levels of the above four indexes in the observation group showed no significant difference compared to those before treatment （P＞0.05）. The observation group had lower levels of FBG， two-hour FINS， TC， and TG compared to those in the control group （P＜0.05）. Within the first week of treatment， the incidence of adverse reactions in the observation group was lower than that in the control group （P＜0.05）. Conclusion： The combination of Jieyu Anshen Capsules and Risperidone in the treatment of schizophrenia of binding constraint of liver qi type can enhance the clinical effect，effectively alleviate symptoms，promote cognitive function recovery，and stabilize the levels of blood glucose and blood lipids，with good medication safety.