Abstract：Objective：To observe the curative effect of fumigation with She medicine Xiaoxianggou on post-stroke stage I shoulder-hand syndrome （SHS）. Methods： A total of 62 patients with post-stroke stage I SHS who were admitted to Lishui City People′s Hospital and not given treatment after the first onset from June 2022 to October 202 were selected and divided into the control group and the observation group according to the random number table method， with 1 cases in each group. The control group was treated with conventional rehabilitation， and the observation group was additionally treated with fumigation with She medicine Xiaoxianggou based on the treatment of the control group. The two groups were treated for two and four weeks，respectively. The changes in pain degree [scores of Visual Analogue Scale （VAS） of pain]， motor function of upper limbs [scores of modified Fugl-Meyer Assessment （FMA） scale]，and scores of Barthel Index （BI） were compared before and after treatment between the two groups. Results：After two and four weeks of treatment，the VAS scores in both groups were reduced when compared with those before treatment，and the VAS score in the observation group was lower than that in the control group at the same stage， differences being significant （P＜0.05）. After two and four weeks of treatment， the FMA scores in both groups were elevated when compared with those before treatment （P＜0.05）， and the FMA score in the observation group was higher than that in the control group at the same stage （P＜0.05）. After two and four weeks of treatment，the BI scores in both groups were increased when compared with those before treatment （P＜0.05），and the BI score in the observation group was higher than that in the control group at the same stage （P＜0.05）. Conclusion：The fumigation with She medicine Xiaoxianggou has a great curative effect on stage ⅠSHS，which can effectively mitigate the pain in the shoulders and hands，and improve the motor function of upper limbs and the activity of daily living.