Abstract： Objective： To observe the curative effect of Danggui Sini Decoction combined with Ebastine on chronic urticaria. Methods： A total of 82 cases of patients with chronic urticaria admitted to Dongyang Traditional Chinese Medicine Hospital from March 2021 to January 2023 were divided into the treatment group and the control group according to the random number table method， with 41 cases in each group. The control group was treated with Ebastine，and the treatment group was treated with Danggui Sini Decoction combined with Ebastine. Clinical effects and the incidence of adverse reactions were compared between the two groups. Changes in Urticaria Activity Score （UAS）， serum immune markers [immunoglobulin E （IgE），interferon-γ （IFN-γ），interleukin-4 （IL-4）]，and chemotactic factors [monocyte chemoattractant protein-1 （MCP-1）， regulated upon activation normal T cell expressed and secreted （RANTES）] before and after treatment were compared between the two groups. Results： The total effective rate of clinical effect was 97.56% （40/41） in the treatment group and 80.49% （33/41） in the control group，with a significant difference between the two groups （P＜0.05）. After treatment，UAS scores in the two groups were decreased when compared with those before treatment （P＜0.05）， with the treatment group showing lower UAS score than the control group （P＜0.05）. The levels of IgE and IL-4 in serum in the two groups were decreased when compared with those before treatment （P＜0.05），and IFN-γ levels in the two groups were increased when compared with those before treatment （P＜0.05）. After treatment，the levels of IgE and IL-4 in serum in the treatment group were lower than those in the control group （P＜0.05），and IFN-γ level was higher than that in the control group （P＜0.05）. After treatment， the levels of MCP-1 and RANTES in the two groups were increased when compared with those before treatment （P＜ 0.05）， with the treatment group showing greater reductions （P＜0.05）. The incidence of adverse reactions was 14.63% （6/41） in the treatment group and 21.95% （9/41） in the control group，with no significant difference between the two groups （P＞0.05）. Conclusion：Danggui Sini Decoction combined with Ebastine has a good curative effect in treating chronic urticaria， which can significantly alleviate clinical symptoms and modulate immune function， with good safety.