Abstract： Objective： To observe the clinical effect of Huanglian Decoction and Chailong Niwei Decoction combined with quadruple therapy on chronic non-atrophic gastritis （CNAG） complicated with erosion. Methods： A total of 144 cases of CNAG patients with erosion of liver-stomach disharmony and spleen and stomach damp-heat types treated at Anyang Hospital of Traditional Chinese Medicine from June 2020 to June 2023 were randomly divided into the control group and the observation group， with 72 cases in each group. The two groups were treated with conventional quadruple therapy， and the observation group was additionally treated with Huanglian Decoction and Chailong Niwei Decoction. Both groups were treated for four weeks. Before and after treatment， the scores of traditional Chinese medicine（TCM） syndromes in the two groups were evaluated. The levels of inflammatory factors [tumor necrosis factor- α（TNF-α）， interleukin-1β （IL-1β） and interleukin-8 （IL-8）] and gastric function indexes [gastrin-17 （G-17）， pepsinogenⅠ（PGⅠ）， and pepsinogenⅡ（PGⅡ）] in serum were measured. The gastric mucosal erosion scores and chronic inflammation scores were evaluated， and the occurrence of adverse reactions during the treatment period was statistically analyzed. The clinical efficacy in the two groups was compared. Results：After four weeks of treatment，the total effective rate in the observation group was higher than that in the control group （P＜0.05）. The main symptom scores， secondary symptom scores， total scores of TCM syndromes and gastric mucosal erosion scores and chronic inflammation scores in the two groups were decreased when compared with those before treatment，and the above five scores in the observation group were lower than those in the control group， the difference being statistically significant （P＜0.05）. The levels of TNF- α， IL-1β， IL-8 and PG Ⅱ in the two groups were decreased when compared with those before treatment （P＜0.05）， and the levels of G-17 and PGⅠ in the two groups were increased when compared with those before treatment （P＜0.05）. The levels of TNF- ɑ， IL-1β， IL-8 and PG Ⅱ in the observation group were lower than those in the control group （P＜0.05）， and the levels of G-17 and PGⅠ in the observation group were higher than those in the control group（P＜0.05）. The incidence of adverse reactions in the observation group was compared with that in the control group，there was no significance in the difference （P＞0.05）. Conclusion：On the basis of quadruple therapy，the addition treatment of Huanglian Decoction and ChaiLong Niwei Decoction can alleviate the symptoms of CNAG patients with erosion of liver-stomach disharmony and spleen and stomach damp-heat types，improve their clinical efficacy，reduce inflammation and gastric mucosal erosion，and have high safety.