补阳还五汤联合利伐沙班治疗气虚血瘀型缺血性脑卒中后下肢深静脉血栓临床研究
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R259

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温州市科技局科研项目(Y20220252)


Clinical Study on Buyang Huanwu Decoction Combined with Rivaroxaban in Treating Deep Venous Thrombosis of Lower Limbs After Ischemic Stroke of Qi Deficiency and Blood Stasis Type
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    摘要:

    目的:观察补阳还五汤联合利伐沙班治疗气虚血瘀型缺血性脑卒中后下肢深静脉血栓(LDVT) 的 疗效。方法:选取2022年7月—2023年6月温州市中西医结合医院收治的118例气虚血瘀型缺血性脑卒中后 LDVT患者,按信封法随机分为对照组及观察组各59例。2组均接受现代医学常规治疗。对照组在常规治疗基 础上加用利伐沙班治疗,观察组在常规治疗基础上加用补阳还五汤联合利伐沙班治疗,2组均治疗14 d。比较 2 组临床疗效,中医证候积分、美国国立卫生研究院脑卒中量表(NIHSS) 评分、日常生活活动能力量 表(Barthel) 评分、Villalta评分和凝血指标[D-二聚体(D-D)、同型半胱氨酸(Hcy)、纤维蛋白原(FIB)、 凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)] 水平。结果:治疗14 d后,观察 组临床疗效总有效率93.10% (54/58) 高于对照组82.76% (48/58)(P<0.05)。治疗7 d、14 d后,2组中医证 候积分均较治疗前降低,且观察组中医证候积分均低于同期对照组(P<0.05);治疗7 d、14 d后,2组NIHSS 评分和Villalta评分均较治疗前降低,观察组NIHSS评分和Villalta评分均低于同期对照组(P<0.05);治疗 14 d后,2组NIHSS评分和Villalta评分均低于治疗7 d后(P<0.05)。治疗7 d、14 d后,2组Barthel评分均较 治疗前升高(P<0.05);治疗14 d 后,2 组Barthel 评分均较治疗7 d 后升高,观察组Barthel 评分高于对照 组(P<0.05)。治疗7 d、14 d后,2组D-D、Hcy、FIB水平均较治疗前降低(P<0.05);治疗14 d后,2组 D-D、Hcy、FIB水平均较治疗7 d后降低(P<0.05)。治疗7 d、14 d后,2组PT、APTT、TT均较治疗前延长, 观察组PT均长于同期对照组(P<0.05);治疗14 d后,2组PT、APTT、TT均较治疗7 d后延长(P<0.05)。 2组均未出现不良反应。结论:补阳还五汤联合利伐沙班治疗气虚血瘀型缺血性脑卒中后LDVT可改善临床症 状,降低D-Dimer及Hcy水平,有效改善凝血功能,发挥协同抗凝作用。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Buyang Huanwu Decoction combined with Rivaroxaban in the treatment of deep veinous thrombosis of lower limbs (LDVT) after ischemic stroke of qi deficiency and blood stasis type.Methods:A total of 118 LDVT patients hospitalized in Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from July 2022 to June 2023 after ischemic stroke with qi deficiency and blood stasis type were randomly divided into control group and observation group with 59 cases in each group according to envelope method. One case in the control group was excluded for fail to take Chinese medicine orally follow doctor's advice,and one case in the observation group was excluded for early discharge from the hospital, and finally, 58 cases in each group completed the study.Both groups received conventional treatment. The control group was treated with Rivaroxaban on the basis of conventional treatment,and the observation group was treated with Buyang Huanwu Decoction combined with Rivaroxaban on the basis of conventional treatment, Both groups were treated for 14 days. The clinical efficacy, tradional Chinese medicine (TCM) syndrome score,Stroke Scale (NIHSS) score,Barthel Index (Barthel) score and Villalta score, blood clotting index [D-Dimer (D-D), homocysteine (Hcy), fibrinogen (FIB), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT)] level of the two groups was compared. Results:After 14 days of treatment,the total effective rate of the observation group was 93.10% (54/58), higher than that of the control group 82.76%(48/58) (P<0.05). After 7 and 14 days of treatment, TCM syndrome scores in the two groups were lower than those before treatment, and TCM syndrome scores in the observation group were lower than those in the control group (P<0.05). After 7 and 14 days of treatment,NIHSS score and Villalta score in the two groups were lower than those before treatment,and NIHSS score and Villalta score in observation group were lower than those in control group (P<0.05). After 14 days of treatment,the NIHSS score and Villalta score in the two groups were lower than that after 7 days of treatment (P<0.05).After 7 and 14 days of treatment,Barthel scores in the two groups were higher than those before treatment (P<0.05). After 14 days of treatment,the Barthel score in the two groups was higher than that after 7 days of treatment,and the observation group was higher than the control group (P< 0.05). After 7 and 14 days of treatment,the levels of D-D,Hcy and FIB in the two groups were lower those than before treatment (P<0.05); after 14 days of treatment, the levels of D-D, Hcy and FIB indexes in the two groups were lower than those after 7 days of treatment (P<0.05). After 7 and 14 days of treatment,PT,APTT and TT in the two groups were longer than those before treatment,and PT in observation group was longer than that in control group at the same period(P<0.05);after 14 days treatment,PT,APTT and TT in the two groups were longer than those after 7 days treatment (P<0.05). There were no adverse reactions in both groups. Conclusion:The combination of Buyang Huanwu Decoction and Rivaroxaban can improve clinical symptoms,reduce D-D and Hcy levels,effectively improve coagulation function,and exert a synergistic anticoagulant effect in the treatment of LDVT after stroke of qi deficiency and blood stasis type.

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姜霞,陈世宣,朱斌,黄琪瑶,陈温慈,计静.补阳还五汤联合利伐沙班治疗气虚血瘀型缺血性脑卒中后下肢深静脉血栓临床研究[J].新中医,2025,57(1):22-27

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  • 在线发布日期: 2025-01-14
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