Abstract：Objective：To observe the clinical effect of Compound Danshen Dripping Pills combined with western medicine on senile patients with coronary heart disease complicated with chronic heart failure. Methods： A total of 116 cases of senile patients with coronary heart disease complicated with chronic heart failure treated at Jiangcun Community Health Service Center，Xihu District，Hangzhou City from March 2020 to May 2023 were divided into the trial group and the control group according to the random number table method，with 58 cases in each group. The control group was treated with western medicine，and the trial group was additionally treated with Compound Danshen Dripping Pills based on the treatment of the control group. Both groups were treated for six consecutive courses.The traditional Chinese medicine （TCM） syndromes scores，New York Heart Association （NYHA） cardiac function grading，and the levels of heart function indexes [left ventricular end-diastolic diameter （LVEDD）， left ventricular end-systolic diameter（ LVESD），left ventricular ejection fraction（ LVEF）]，lipoprotein-associated phospholipase A2（ LP-PLA2）， heart-type fatty acid-binding protein （hFABP），and soluble growth stimulation expressed gene 2 protein （sST2） in the two groups were compared before and after treatment. Clinical effects and adverse reactions in the two groups were evaluated. Results：After treatment，the total effective rate was 94.83%（ 55/58） in the trial group，higher than that of 79.31% （46/58） in the control group （P＜0.05）. The NYHA cardiac function grading in the two groups after treatment was milder than that before treatment （P＜0.05）， and the NYHA cardiac function grading in the trial group was relieved compared to the control group （P＜0.05）. After treatment，TCM syndrome scores and the levels of LVEDD， LVESD， hFABP， LP-PLA2， and sST2 in the two groups were decreased when compared with those before treatment（ P＜0.05），and LVEF levels were increased（ P＜0.05）；the TCM syndrome score and the levels of LVEDD， LVESD，hFABP，LP-PLA2，and sST2 in the trial group were lower than those in the control group （P＜0.05），and the LVEF level was higher than that in the control group （P＜0.05）. The incidence of adverse reactions was 1.72% （1/ 58） in the trial group， lower than that of 12.07% （7/58） in the control group （P＜0.05）. Conclusion： Compound Danshen Dripping Pills combined with western medicine has a definite curative effect in treating senile patients with coronary heart disease complicated with chronic heart failure，which can significantly enhance their heart function and reduce myocardial inflammatory injury，with high safety.