温阳散寒消痹外洗方联合西洛他唑治疗阳虚寒凝型糖尿病周围神经病变临床研究
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R259

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临海市科技计划项目(202YW28)


Clinical Study on Wenyang Sanhan Xiaobi External Washing Prescription Combined with Cilostazol for Diabetic Peripheral Neuropathy of Yang Deficiency and Congealing Cold Type
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    摘要:

    目的:观察温阳散寒消痹外洗方联合西洛他唑治疗阳虚寒凝型糖尿病周围神经病变(DPN) 的临 床疗效。方法:选取202年1月—2024年2月临海市中医院收治的104例阳虚寒凝型DPN患者,按照随机数字 表法分为研究组和对照组各52例。对照组给予西洛他唑口服治疗,研究组在对照组基础上给予温阳散寒消痹 外洗方足浴治疗,2组均治疗4周。比较2组临床疗效、中医证候积分、多伦多临床神经病变量表(TCSS) 评 分、神经传导速度、动脉血流速度和不良反应发生情况。结果:研究组总有效率9.88%(46/49),高于对照组 79.59%(9/49)(P<0.05);2组肢体麻木不仁、肢末冷痛、畏寒怕凉、腰膝酸冷、神疲乏力、倦怠懒言积分 及TCSS评分均较治疗前降低(P<0.05),研究组肢上述6项中医证候积分及TCSS评分均低于对照组(P< 0.05);2组腓总神经、正中神经、胫后神经的感觉神经传导速度(SCV) 和运动神经传导速度(MCV) 及双侧 腘、足背动脉血流速度均较治疗前加快(P<0.05),研究组腓总神经、正中神经、胫后神经的SCV、MCV及双 侧腘、足背动脉血流速度均快于对照组(P<0.05)。结论:温阳散寒消痹外洗方联合西洛他唑可进一步改善阳 虚寒凝型DPN患者的临床症状,加快神经传导速度和下肢动脉血流速度,疗效较好,且具有良好的安全性。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Wenyang Sanhan Xiaobi External Washing Prescription combined with Cilostazol on diabetic peripheral neuropathy (DPN) of yang deficiency and congealing cold type. Methods: A total of 104 DPN patients of yang deficiency and congealing cold type admitted to Linhai Hospital of Traditional Chinese Medicine from January 202 to February 2024 were randomly divided into the study group and the control group,with 52 patients in each group,using a random number table method. The control group received oral treatment with Cilostazol, while the study group received foot bath treatment with Wenyang Sanhan Xiaobi External Washing Prescription on the basis of the control group. Both groups were treated for four weeks. Compared the clinical efficacy, traditional Chinese medicine(TCM) syndrome scores, Toronto Clinical Scoring System (TCSS) scores, nerve conduction velocity, lower limb arterial blood flow velocity and incidence of adverse reactions between the two groups. Results: The total effective rate was 9.88% (46/49) in the study group, which was higher than that of 79.59% (9/49) in the control group (P<0.05). The scores of TCM syndromes including numbness in the limbs,cold pain at the end of the limbs, aversion of coldness, soreness and coldness in the waist and knees, fatigue and weakness,and laziness in speech and TCSS scores in the two groups were lower than those before treatment (P<0.05), and the scores of TCM syndromes and TCSS in the study group were lower than those in the control group (P<0.05). The sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) of common peroneal nerve, median nerve, and posterior tibial nerve, as well as the blood flow velocity of the bilateral popliteal and dorsal foot arteries in the two groups were all increased when compared with those before treatment (P<0.05). The SCV and MCV of the common peroneal nerve, median nerve, and posterior tibial nerve, as well as the blood flow velocity of the bilateral popliteal and dorsal foot arteries in the study group were faster than those in the control group (P<0.05). Conclusion: The combination of Wenyang Sanhan Xiaobi External Washing Prescription and Cilostazol can further improve the clinical symptoms of DPN patients of yang deficiency and congealing cold, accelerate nerve conduction velocity and lower limb arterial blood flow velocity,with good therapeutic effect and good safety.

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郑苏,丁艺.温阳散寒消痹外洗方联合西洛他唑治疗阳虚寒凝型糖尿病周围神经病变临床研究[J].新中医,2025,57(3):68-72

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  • 在线发布日期: 2025-02-22
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