Abstract：Objective：To observe the curative effect of applying ginger powder to Neiguan（ PC 6） point combined with Tropisetron in preventing postoperative nausea and vomiting （PONV） after gynecological laparoscopy. Methods： A total of 72 cases of patients treated with gynecological laparoscopr at Hangzhou Red Cross Hospital from January 2022 to June 2023 were selected and divided into the control group and the observation group according to the random number table method， with 36 patients in each group. After surgery， the control group was given Tropisetron Hydrochloride Injection，while the observation group was additionally given ginger powder patch on the Neiguan（ PC 6） point on the basis of the control group. Compared the PONV incidence， the time of first PONV， the frequency of postoperative PONV occurrence，and the degree of PONV occurrence between the two groups. Compared the changes in anxiety， depression [Self-Rating Anxiety Scale （SAS）， and Self-Rating Depression Scale （SDS）]， and quality of life [36-Item Short Form Health Survey （SF-36）] before and after surgery between the two groups. Results： The control group consisted of 25 cases of PONV， with an incidence rate of 69.44% （25/36）； the observation group consisted of 16 cases of PONV， with an incidence rate of 44.44% （16/36）； there was significant difference in the incidence rates of PONV between the two groups （P＜0.05）. The observation group had a later onset of postoperative PONV，and the frequency of PONV occurrence in each time period was lower than that in the control group （P＜0.05）. As time progressed，the PONV levels in both groups were gradually decreased （P＜0.05） at 8 hours，24 hours，and 48 hours after surgery. The PONV degree in the observation group were lower than those in the control group at all time points （P＜0.05）. The DA and NE levels in both groups were increased at 48 hours after surgery compared to the preoperative levels （P＜0.05），and there was no significant difference between the two groups （P＞0.05）. At 48 hours after surgery，both groups showed a decrease in SAS and SDS scores compared to the preoperative levels （P＜0.05）， with the observation group having lower SAS and SDS scores than the control group （P＜0.05）. At 48 hours after surgery， both groups showed an increase in SF-36 scores compared to preoperative levels （P＜0.05）， with the observation group having a higher SF-36 score than the control group （P＜0.05）. Conclusion：Applying ginger powder to Neiguan（ PC 6） point combined with Tropisetron in preventing PONV after gynecological laparoscopy can reduce the PONV incidence， delay the first PONV time， reduce the frequency and degree of PONV occurrence， is helpful for alleviate patients' anxiety and depression，and improve postoperative quality of life.