Abstract：Chronic kidney failure is a chronic，progressive，and occult deficiency syndrome caused by damage to the kidneys themselves，other viscera diseases，or other factors. Based on the theory of spleen and kidney related to the five organs，Professor LI Shunmin，a renowned traditional Chinese medicine practitioner in Guangdong Province，has summarized an empirical prescription for treating chronic kidney failure - Jianpi Yishen Prescription. This prescription is quite effective in clinical practice，and its treatment approach is similar to the circular motion theory. Therefore，this article combines with the circular motion theory to analyze the pathogenesis of chronic kidney failure and the prescription and medication approach of Jianpi Yishen Prescription.