Abstract： Explores the etiology， pathogenesis， and treatment of influenza in the Lingnan region from the perspective of the epidemic theory of Chinese medicine. The main cause of influenza in Lingnan region is epidemic toxin， supplemented by dampness pathogen，which forming a complex etiology. The pathogenesis evolution of influenza in the Lingnan region was divided into five stages and proposing a staged treatment strategy： ① In the initial stage， the disease is located in the lung defense and muscle surface， and the treatment should be acrid-cool dispersing， dispelling dampness and penetrating the pathogen；②When the epidemic toxin enters the interior and damages the lung collaterals， the treatment should be clearing heat， draining dampness， resolving blood stasis and detoxifying； ③When dampness and phlegm obstruct，and toxin and stasis bind together，causing critical syndromes，the treatment should be unblocking the fu organs，purging heat，removing dampness and turbidity；④In the critical stage，when the healthy qi is deficient and the pathogen is lingering， with both yin and yang deficiency， the treatment should be warming yang and dissolving dampness or boosting qi and nourishing yin；⑤In the recovery stage，with yin damage， qi consumption， and residual pathogens， the treatment should be boosting qi， nourishing yin， strengthening the spleen and removing dampness. The staged treatment strategy proposed in this study is based on the characteristics of the Lingnan region， emphasizing the importance of dampness-removing methods and rationally using authentic Lingnan medicinal materials.