Abstract：Objective：To study the main components and mechanism of Rehmanniae Radix-Trichosanthis Radix in treating diabetes by using network pharmacology and molecular docking technology. Methods： The main active components and targets of Rehmanniae Radix-Trichosanthis Radix were obtained by TCMSP， herb and Swiss Target Prediction databases. The main targets of diabetes were screened through GeneCard，OMIM and other databases；the intersection targets of the two were obtained by Venn diagram；the PPI network was drawn；the drug-active componenttarget network was constructed，and the core targets and components of Rehmanniae Radix-Trichosanthis Radix in the treatment of diabetes were further obtained. Gene Ontology （GO） and Kyoto Encyclopedia of Genes and Genomes（KEGG） pathway enrichment analysis were carried out through the David database，and the molecular docking between core targets and corresponding active components was verified by AutoDock-Vina. Results：A total of 15 nonrepetitive active components and 464 action targets were selected from Rehmanniae Radix-Trichosanthis Radix， and they were intersected with 1 455 diabetes related targets， and eventually 157 intersection targets were obtained. The core active components of Rehmanniae Radix-Trichosanthis Radix in treating diabetes were Galanal A，Spinasterol，6- Hydroxy-3- （1-hydroxy-1-methylethyl） -6，10，12a-trimethyl-1，2，3，3 a，4，5，6，9，10，12a-decahydrocyclopenta [a] cycloundecen-4-yl acetate and sterol（Schottenol），and the core targets were IL1B，PPARG，DPP4，PTGS2 and EGFR. The signaling pathway analysis showed that Rehmanniae Radix-Trichosanthis Radix could intervene in diabetes through a variety of signaling pathways， including Pathways in Cancer， Insulin Resistance， and PPAR signaling pathway. The results of molecular docking showed that the main active components and the target proteins had good binding activity. Conclusion： Rehmanniae Radix-Trichosanthis Radix can play an effective role in the treatment of diabetes through multiple components，multiple targets and multiple ways.