Abstract：Objective：To observe the clinical effect of Quzhuo Shengji Ointment on prognosis after operation for high perianal abscess. Methods：A total of 92 patients after operation for high perianal abscess admitted to the General Hospital of Hebi Coal Industry （Group） Co.，Ltd. from September 2021 to December 2022 were selected and divided into the control group and the trial group by random number table method， with 46 patients in each group. The two groups were treated with high ligation therapy for anal fistula. The control group was treated with western medicine after operation， and the trial group was additionally treated with Quzhuo Shengji Ointment based on the treatment of the control group. The traditional Chinese medicine （TCM） syndrome scores， scores of Visual Analogue Scale （VAS）， wound drainage score， anal canal maximum systolic blood pressure， anal canal resting pressure， serum levels of interleukin-1β （IL-1β），tumor necrosis factor-α （TNF-α），interleukin-8 （IL-8） and vascular endothelial growth factor （VEGF） were compared between the two groups before and after treatment. The granulation growth score，wound healing time，clinical effects and the incidence of adverse reactions were compared between the two groups. Results： The total effective rate was 95.65% （44/46） in the trial group， and was 7.91% （4/46） in the control group. After treatment， the TCM syndrome scores， VAS scores， wound draining scores， the anal canal maximum systolic blood pressure，anal canal resting pressure and levels of serum TNF-α，IL-1β and IL-8 were decreased in both groups when compared with those before treatment （P＜0.05）， and serum VEGF levels were increased （P＜0.05）； the TCM syndrome scores， VAS score， wound drainage score and levels of serum inflammatory factors in the trial group were lower than those in the control group （P＜0.05）， and the anal canal maximum systolic blood pressure， anal canal resting pressure and serum VEGF levels in the trial groups were higher than those in the control group （P＜0.05）. The granulation growth score in the trial group was lower than that in the control group （P＜0.05），and the wound healing time was shorter than that in the control group （P＜0.05）. No adverse reactions occurred in both groups. Conclusion： The adjuvant treatment of Quzhuo Shengji Ointment can reduce the inflammatory responses of patients， relieve the wound pain，promote the growth of granulation and the recovery of anal function，with significant effect and high safety.