Clinical Study on Yiqi Wenyang Tongbi Prescription Combined with Western Medicine for Lumbar Disc Herniation of Kidney Deficiency and Blood Stasis Type
Abstract:Objective:To observe the clinical effect of the therapy of Yiqi Wenyang Tongbi Prescription combined with western medicine on lumbar disc herniation (LDH) of kidney deficiency and blood stasis type. Methods:A total of 60 LDH patients of kidney deficiency and blood stasis type who were treated at the Clinic of Spine Department of Guangdong Provincial Hospital of Chinese Medicine from March 2023 to March 2024 were enrolled and divided into the control group and the trial group according to the random number table method,with 30 patients in each group. Both groups were treated with Etoricoxib Tablets and Mecobalamin Tablets. The trial group was additionally treated with Yiqi Wenyang Tongbi Prescription. Both groups were treated for four weeks. The traditional Chinese medicine syndrome scores,and the scores of Visual Analogue Scale (VAS) of lumbar pain,Japanese Orthopaedic Association (JOA) of low back pain, and Oswestry Disability Index (ODI) in both groups before and after treatment were evaluated; the clinical effects in the two groups were evaluated,and the incidence of adverse reactions was observed. Results:After four weeks of treatment,there were no significant difference being found in the comparison of the total effective rate and the clinical efficacy between the two groups (P>0.05). After treatment, the scores of low back pain, soreness and weakness of waist and knees, pale complexion and cold extremities, weakness and numbness of lower limbs, and limited mobility,and the total scores in both groups showed a decreasing trend;there were significant difference being found in the comparison of the data at each time point in both groups (P<0.05). After two weeks of treatment, the above scores in both groups were respectively dwindled when compared with those before treatment,differences being significant (P<0.05). After four weeks of treatment, the above scores in both groups were down-regulated when compared with those before treatment and after two weeks of treatment,differences being significant (P<0.05);the above scores in the trial group were lower than those in the control group (P<0.05). After treatment,the scores of VAS and ODI in both groups showed a decreasing trend,the scores of JOA in both groups showed a increasing trend;there were significant differences being found in the comparisons of the above three scores at each time point in the two groups (P<0.05). After two weeks of treatment, the scores of VAS and ODI in both groups were reduced when compared with those before treatment,the scores of JOA in both groups were increased when compared with those before treatment, the difference being significant (P<0.05); there were no significant differences being found in the comparisons of the above three scores between the two groups (P>0.05). After four weeks of treatment,the scores of VAS and ODI in both groups were down-regulated when compared with those before treatment and after two weeks of treatment, the scores of JOA in both groups were elevated when compared with those before treatment and after two weeks of treatment,differences being significant (P<0.05);the scores of VAS and ODI in the trial group were lower than those in the control group, the score of JOA was higher than that in the control group, differences being significant (P<0.05). No adverse reactions occurred in either group during treatment. Conclusion: The therapy of Yiqi Wenyang Tongbi Prescription combined with Etoricoxib Tablets and Mecobalamin Tablets can improve the symptoms and lumbar function of LDH patients of kidney deficiency and blood stasis type,enhance their quality of life. This therapy demonstrates certain advantages over the treatment with Etoricoxib Tablets combined with Mecobalamin Tablets in terms of curative effect,and has better security.