Abstract： Objective： To observe the clinical effect of straight and side needling method combined with spinal tuina on cervical spondylotic radiculopathy （CSR） with qi stagnation and blood stasis syndrome. Methods：A total of 183 cases of CSR patients with qi stagnation and blood stasis syndrome treated at Wenling Traditional Chinese Medicine Hospital from January 2022 to December 2023 were divided into the control group 1， the control group 2， and the combination group， using a random number table method， with 61 patients in each group. The control group 1 was treated with straight and side needling method，and the control group 2 was treated with spinal tuina therapy，and the combination group was treated with straight and side needling method combined with spinal tuina. All the three groups were treated for four weeks. Compared the clinical effect， traditional Chinese medicine （TCM） syndrome scores， cervical physiological curvature，cervical mobility，McGill pain questionnaire scores，and pain mediators levels in the three groups. Results：After four weeks of treatment，the total effective rate was 93.44% （57/61） in the combination group，which were higher than those of 75.41% （46/61） in the control group 1 and the 73.77% （45/61） in the control group 2 （P＜0.017）. The TCM syndrome scores in the three groups were decreased when compared with those before treatment（ P＜0.05），and the TCM syndrome scores in the combination group were lower than those of the control group 1 and the control group 2 （P＜0.05）. The cervical physiological curvatures in all the three groups were increased when compared with those before treatment （P＜0.05），and the cervical physiological curvature in the combination group was greater than those in the control group 1 and the control group 2 （P＜0.05）. The range of motion for cervical flexion， extension， lateral flexion， and rotation in all three groups were increased when compared with those before treatment （P＜0.05）， and the range of motion for cervical flexion， extension， lateral flexion， and rotation in the combination group were greater than those in the control group 1 and the control group 2 （P＜0.05）. The pain rating index（ PRI），visual analogue scale（ VAS），and present pain intensity（ PPI） scores in the three groups were decreased when compared with those before treatment （P＜0.05），and the PRI，VAS，and PPI scores in the combination group were lower than those in the control group 1 and the control group 2 （P＜0.05）. The levels of prostaglandin E2 and substance P in all the three groups were decreased when compared with those before treatment （P＜0.05）， and the levels of prostaglandin E2 and substance P in the combination group were lower than those in the control group 1 and the control group 2 （P＜0.05）. Conclusion： The combination of straight and side needling method and spinal tuina can alleviate the neck symptoms and signs of CSR patients with qi stagnation and blood stasis syndrome，improve cervical mobility，and have better therapeutic effects than using only straight and side needling method or spinal tuina.