Abstract：Objective：Comparative study on the clinical effect of multi-needle cluster needling and conventional acupuncture combined with flash cupping therapy on intractable facial paralysis. Methods：A total of 80 patients with intractable facial paralysis treated at Wenzhou People's Hospital from February 2022 to February 2024 were selected and divided into the control group and the observation group，using a random number table method，with 40 cases in each group. The control group was treated with conventional acupuncture combined with flash cupping，while the observation group was treated with multi-needle cluster needling combined with flash cupping. Ten times of treatment constitute one course of treatment， and both groups received three courses of treatment. Compared the clinical efficacy， House- Brackmann （H-B） scores， Facial Disability Index （FDI） scores， as well as the amplitude and latency of the orbicularis oculi muscle conduction on the affected side between the two groups. Results： After three courses of treatment，the total effective rate was 92.50% in the observation group （37/40），which was higher than that of 75.00% in the control group （30/40），the difference being significant （P＜0.05）. The sub-item scores and total scores of H-B in both groups were increased when compared with those before treatment， and the sub-item score and total score of H-B in the observation group were higher than those in the control group，differences being significant （P＜0.05）. Both groups showed a decrease in Facial Disability Index Social Function （FDIS） scores when compared with those before treatment，and an increase in Facial Disability Index Physical Function （FDIP） scores when compared with those before treatment，differences being significant （P＜0.05）；the FDIS score in the observation group was lower than that in the control group，while the FDIP score was higher than that in the control group，differences being significant （P＜0.05）. Both groups showed an increase in the amplitude of the orbicularis oculi muscle conduction wave on the affected side when compared with that before treatment，and a decrease in the latency of orbicularis oculi muscle conduction on the affected side when compared with that before treatment， differences being significant （P＜0.05）； the amplitude of orbicularis oculi muscle conduction wave on the affected side in the observation group was greater than that in the control group，and the latency of orbicularis oculi muscle conduction on the affected side was shorter than that in the control group， differences being significant （P＜0.05）. Conclusion： The combination of multi-needle cluster needling and conventional needling combined with flash cupping therapy can improve the symptoms of intractable facial paralysis and promote the recovery of facial nerve function，but the combination of multi-needle cluster needling and flash cupping therapy is more effective.