Abstract： Objective： To study the clinical treatment scope， compatibility rule and operation technique of Guanyuan （RN4） based on data mining techniques. Methods：Using the 5th edition of the Chinese Medical Dictionary as the source database，searched with keywords such as Guanyuan（ RN4），Dantian，Dazhongji，Sanjiejiao，Cimen， Xiaji ， and Xiaochangmu ， and collected， organized， and classified the obtained literature. Results ： A total of 3 501 articles were retrieved，involving 112 ancient medical books. According to the inclusion and exclusion criteria， 363 articles were finally included. A total of 349 articles were included regarding the treatment of diseases and syndromes， and 14 articles were included explaining procedures or contraindications； the frequency of single point treatment was 135 times， and the frequency of combination treatment was 328 times. The single point treatment and combination treatment of Guanyuan （RN 4） point were multiple and various. The top two diseases that can be treated with single point therapy were syncope and consumptive disease， while the top two diseases that can be treated with combination therapy were syncope and hernia disease. The most common points were Qihai（ RN 6），Sanyinjiao（ SP 6）， Shenshu （BL 23），Shimen （RN 5），Zhongwan （RN 12），Shenque （RN 8），Zusanli （ST 36），Tianshu （ST 25）， Zhongji （RN 3），and Taichong （LV 3）；The points used for compatibility mostly belong to the conception vessel and the foot taiyang bladder channel. There was a significant correlation between Guanyuan （RN 4） and Qihai （RN 6）， Sanyinjiao（ SP 6），Shenshu（ BL 23），Shimen（ RN 5），Shenque（ RN 8），Zhongwan（ RN 12），and Zusanli（ ST 36）. Cluster analysis of high-frequency points resulted in six effective clusters. Guanyuan （RN 4） often used moxibustion methods， with varying amounts of moxibustion， mostly with hundred of moxa； pregnant women and summer moxibustion should be cautious. Conclusion：The first indication for the use of single point and combination therapy of Guanyuan （RN 4） point is syncope. The common points for compatibility belong to the conception vessel and the foot taiyang bladder channel. Guanyuan （RN 4） is often used in combination with Qihai （RN 6）， Sanyinjiao （SP 6）， Shenshu（ BL 23）. Six effective clustering combinations are obtained；the main operation method is moxibustion.