Abstract： Objective： To observe the clinical effect of the modified arc-blade needle knife combined with Qianghuo Shengshi Decoction in the treatment of cervical spondylotic radiculopathy （CSR） of wind-cold obstruction type. Methods：A total of 79 CSR patients of wind-cold obstruction type admitted to Zhumadian Traditional Chinese Medicine Hospital from December 2019 to December 2021 were selected as the research subjects；they were randomly divided into a study group and a control group according to the random number table method，with 40 and 39 cases in each group respectively. Both groups were treated with Qianghuo Shengshi Decoction. The control group received traditional needle knife treatment based on Qianghuo Shengshi Decoction，while the study group received modified arcblade needle knife treatment based on Qianghuo Shengshi Decoction. Both groups were treated for three weeks. Clinical effects， symptom scores， levels of serum inflammatory factors [interleukin-1β （IL-1β） and tumor necrosis factor- α （TNF- α）]， pain factors [substance P （SP） and prostaglandin E2 （PEG2）]， average flow velocity of vertebral artery （VA） and basilar artery （BA）， cervical range of motion （flexion-extension and rotation）， Neck Disability Index （NDI） scores， and Visual Analogue Scale （VAS） scores were compared between the two groups. After a sixmonth follow-up after treatment， the recurrence rates were compared. Results： The total effective rate in the study group was 97.50% （39/40）， which was higher than the control group's 79.49% （31/39） （P＜0.05）. Both groups showed a decreasing trend in the scores of neck，shoulder，and back discomfort，upper limb numbness and pain，and finger numbness and pain after one week of treatment， and after three weeks of treatment （P＜0.05）； the scores of neck， shoulder， and back discomfort， upper limb numbness and pain， and finger numbness and pain in the study group were lower than those in the control group after one week and three weeks of treatment （P＜0.05）. The levels of serum IL-1β，TNF-α，SP，and PGE2 showed a decreasing trend after one week of treatment，and after three weeks of treatment in the two groups（ P＜0.05）；the levels of serum IL-1β，TNF-α，SP，and PGE2 in the study group were lower than those in the control group after one week and three weeks of treatment （P＜0.05）. The average flow rates of VA and BA showed an increasing trend after one week of treatment， and after three weeks of treatment in the two groups （P＜0.05）；the average flow rates of VA and BA in the study group were higher than those in the control group after one week and three weeks of treatment （P＜0.05）. Both groups showed an increasing trend in cervical flexion， extension，and rotational range of motion after one week of treatment，and after three weeks of treatment （P＜0.05）； after one week and three weeks of treatment，the cervical flexion，extension，and rotation range of motion in the study group were higher than those in the control group （P＜0.05）. The two groups showed a decreasing trend in NDI scores and VAS scores after one week of treatment，and after three weeks of treatment （P＜0.05）；after one week and three weeks of treatment， NDI scores and VAS scores in the study group were lower than those in the control group （P＜ 0.05）. The recurrence rate in the study group was 5.13% （2/39），which was lower than the control group's 29.03% （9/ 31）（χ2=7.451， P＜0.05）. Conclusion： The modified arc-blade needle knife combined with Qianghuo Shengshi Decoction can improve blood circulation， reduce cervical dysfunction， increase cervical mobility， inhibit the expression of inflammation-pain factors， alleviate patients' symptoms， and reduce the risk of recurrence in patients with CSR of wind-cold obstruction syndrome.