Abstract： Objective： Using data mining to analyze the medication rules of renowned traditional Chinese medicine practitioner Professor CHENG Zuyao in treating flat warts， and to summarize Professor CHENG Zuyao's academic ideas on treating flat warts. Methods： Collected Chinese medicine prescriptions for flat warts from patients who visited the expert clinic of CHENG Zuyao at Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University from January 2021 to September 2024， input the diagnosis and treatment data into the Traditional Chinese Medicine Inheritance Assistance System，and used the statistical analysis and prescription analysis modules in the V3.5 platform to analyze the frequency of Chinese medicine medication， including its properties， flavors，channel entry，and efficacy. Conducted association rule analysis of Chinese medicine medication and cluster prescription analysis based on the k-means algorithm. Results： This study included a total of 86 prescriptions， involving 46 Chinese medicinals，with a total medication frequency of 969 times. The most frequently used medication was Glycyrrhizae Radix et Rhizoma，followed by Portulacae Herba，Isatidis Folium，Coicis Semen，Equiseti Hiemalis Herba， etc； the frequency analysis of drug efficacy showed that heat-clearing drugs are the main ones， followed by deficiency-tonifying drugs， urination-promoting and dampness-percolating drugs， exterior-releasing drugs， and blood-invigorating and stasis-dissolving drugs；the frequency analysis of drug properties and flavors showed that cold drugs are the main ones， followed by neutral， warm， and cool drugs， that the sweet drugs are the main ones， followed by bitter，sour，pungent，and salty drugs；the analysis of meridian frequency showed that the heart channel is the main one， followed by the liver channel， spleen channel， lung channel， and kidney channel； through association rule analysis，28 drug combinations were obtained，with Portulacae Herba-Isatidis Folium-Coicis Semen- Glycyrrhizae Radix et Rhizoma as the core drug combination； four core prescriptions were obtained through cluster analysis. Conclusion：Professor CHENG Zuyao's clinical diagnosis and treatment of flat warts often use heat-clearing and toxins-resolving drugs，supplemented by spleen-fortifying and dampness-dispelling，blood-nourishing and bloodactivating drugs，reflecting the academic idea of clearing heat to dispel pathogen and regulating stomach to strengthen the foundation.