大补元煎合通瘀煎联合西医治疗肾虚血瘀型多囊卵巢综合征临床研究
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中图分类号:

R711.75

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广东省中医药局中医药科研面上项目(20222218)


Clinical Study on Dabuyuan Decoction and Tongyu Decoction Combined with Western Medicine for Polycystic Ovary Syndrome of Kidney Deficiency and Blood Stasis Type
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    摘要:

    目的:观察大补元煎合通瘀煎联合西医治疗肾虚血瘀型多囊卵巢综合征(PCOS) 的临床疗效及其 对血清促卵泡生成激素(FSH)、促黄体生成激素(LH)、睾酮(T) 水平的影响。方法:选择2022年1月— 2023年12月广州中医药大学顺德医院及广州市增城区妇幼保健院收治的100例肾虚血瘀证PCOS患者,按随机 数字表法分为观察组及对照组,每组50例。对照组采用炔雌醇环丙孕酮片等西药常规治疗,观察组在对照组 基础上加用大补元煎合通瘀煎治疗。连续治疗3个月经周期,评估2组临床疗效,以及治疗前后中医证候学评 分、血清FSH、LH、LH/FSH、T水平变化。结果:治疗后,观察组总有效率为98.00% (49/50),对照组为 84.00%(42/50),组间比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均较治疗前降低(P< 0.05),且观察组评分低于对照组(P<0.05)。治疗后,2组FSH、LH、LH/FSH、T水平均较治疗前降低(P< 0.05),且观察组LH、LH/FSH、T水平低于对照组(P<0.05);但2组FSH水平比较,差异无统计学意义(P> 0.05)。结论:大补元煎合通瘀煎联合炔雌醇环丙孕酮片治疗可改善肾虚血瘀型PCOS患者中医证候及性激素水 平,对促进卵巢功能恢复方面具有积极作用。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Dabuyuan Decoction and Tongyu Decoction combined with western medicine on polycystic ovary syndrome (PCOS) of kidney deficiency and blood stasis type,and its effects on the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) in serum. Methods:A total of 100 cases of patients with PCOS of kidney deficiency and blood stasis type,who were treated at Shunde Hospital of Guangzhou University of Chinese Medicine and Guangzhou Zengcheng Maternal and Child Health Hospital from January 2022 to December 2023, were selected and divided into the observation group and the control group according to the random number table method,with 50 cases in each group. The control group was given routine western medicine treatment,including the oral administration of Ethinylestradiol Cyproterone Acetate Tablets,and the observation group was additionally treated with Dabuyuan Decoction combined with Tongyu Decoction based on the treatment of the control group. Both groups were treated for three menstrual cycles. Traditional Chinese medicine(TCM) syndrome scores,and changes in the levels of FSH,LH,LH/FSH,and T in serum before and after treatment as well as the clinical effects were evaluated in the two groups. Results: After treatment, the total effective rate was 98.00% (49/50) in the observation group and 84.00% (42/50) in the control group, with a significant difference between the groups (P<0.05). After treatment, the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P<0.05), and the score in the observation group was lower than that in the control group (P<0.05). After treatment,the levels of FSH,LH,LH/FSH,and T in the two groups were reduced when compared with those before treatment (P<0.05), with the observation group showing lower levels of LH, LH/FSH ratio, and T than the control group (P<0.05). However, there was no significant difference in FSH levels between the two groups (P>0.05). Conclusion: Dabuyuan Decoction and Tongyu Decoction combined with Ethinylestradiol Cyproterone Acetate Tablets has a positive effect on improving TCM syndromes and sex hormone levels, and promoting ovarian function recovery in patients with PCOS of kidney deficiency and blood stasis type.

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刘福珍,严孟瑜,万水云,陈美玉.大补元煎合通瘀煎联合西医治疗肾虚血瘀型多囊卵巢综合征临床研究[J].新中医,2025,57(6):32-35

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  • 在线发布日期: 2025-03-26
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