Abstract： Objective： To observe the clinical effect of Huatan Tongluo Decoction combined with scalp acupuncture on cerebral infarction and its effects on the levels of oxidative stress and inflammatory factors. Methods：A retrospective analysis was conducted on 62 cases of patients with cerebral infarction treated at Hangzhou Fuyang Hospital of Traditaional Chinese Medicine from January 2022 to January 2024. The patients were divided into the control group （30 cases） and the observation group （32 cases） based on different treatment methods. Both groups received conventional western medical treatment； the control group was additionally treated with scalp acupuncture， and the observation group was additionally treated with Huatan Tongluo Decoction combined with scalp acupuncture. Clinical effects and adverse reactions were observed in the two groups. The levels of neurological function [National Institutes of Health Stroke Scale （NIHSS） scores， Mini-Mental State Examination （MMSE） scores]， oxidative stress indexes [superoxide dismutase （SOD）， malondialdehyde （MDA）， total antioxidant capacity （TAOC）]， and inflammatory factors [high mobility group protein B1 （HMGB1）， tumor necrosis factor-α （TNF-α）， interleukin-6 （IL-6）] in the two groups were compared before and after treatment. Results：After treatment，the total effective rate was 84.38%（ 27/32） in the observation group and 60.00%（ 18/30） in the control group，with a significant difference between the two groups （P＜0.05）. After treatment， NIHSS scores in the two groups were decreased when compared with those before treatment （P＜0.05），and MMSE scores were increased when compared with those before treatment （P＜0.05）. The observation group had lower NIHSS score and higher MMSE score compared to the control group （P＜0.05）. After treatment， MDA levels in the two groups were reduced when compared with those before treatment （P＜0.05）， and the levels of SOD and T-AOC were increased when compared with those before treatment （P＜0.05）；the observation group had lower MDA level and higher levels of SOD and T-AOC compared to the control group （P＜0.05）. After treatment， the levels of HMGB1， TNF- α， and IL-6 in the two groups were significantly decreased when compared with those before treatment （P＜0.05）， with the observation group showing lower levels of these indicators compared to the control group （P＜0.05）. During the treatment period，the incidence of adverse reactions was 9.38%（ 3/32） in the observation group and 3.33%（ 1/30） in the control group，with no significant difference between the two groups （P＞0.05）. Conclusion：On the basis of conventional western medicine treatment， the additional application of Huatan Tongluo Decoction combined with scalp acupuncture can improve clinical effect， effectively reduce oxidative stress and inflammatory responses， and promote the recovery of neurological function in patients with cerebral infarction.