Abstract：Objective：To investigate the effect of wrist-ankle acupuncture combined with Zigan Bushen Tongbian Decoction on the defecation status and maximum tolerance threshold of the rectum in patients with post-stroke constipation of the liver-kidney deficiency type. Methods： A total of 80 patients with post-stroke constipation of the liver-kidney deficiency type admitted to the Seventh People's Hospital of Wenzhou from January 2022 to January 2024 were randomly divided into a single medicine group and an acupuncture-medicine group，with 40 patients in each group. The single medicine group was treated with Zigan Bushen Tongbian Decoction，and the acupuncture-medicine group was given wrist-ankle acupuncture combined with Zigan Bushen Tongbian Decoction. Clinical efficacy， traditional Chinese medicine（ TCM） syndrome scores，defecation status，maximum tolerance threshold of rectum，and the Patient Assessment of Constipation Quality of Life （PACQOL） scores of constipation patients were compared between the two groups. Results：The total effective rate in the acupuncture-medicine group was 97.50% （39/40），while that in the single medicine group was 72.50%（ 29/40）；the difference was significant（ P＜0.05）. After treatment，the TCM syndrome scores in the two groups were declined compared to those before treatment （P＜0.05），and the scores in the acupuncture-medicine group was lower than that in the single medicine group （P＜0.05）. After treatment，the scores of defecation frequency， defecation time， and fecal from in the two groups were decreased compared to those before treatment（ P＜0.05），and the above three scores in the acupuncture-medicine group were lower than those in the single medicine group （P＜0.05）. After treatment， the maximum tolerance threshold of the rectum and anus in both groups was decreased compared to that before treatment （P＜0.05），and the maximum tolerance threshold of the rectum and anus in the acupuncture-medicine group was lower than that in the single medicine group （P＜0.05）. After treatment， the PACQOL scores in both groups were declined compared to those before treatment （P＜0.05）， and the PACQOL scores in the acupuncture-medicine group were lower than those in the single medicine group （P＜0.05）. Conclusion： The combination of wrist-ankle acupuncture and Zigan Bushen Tongbian Decoction can effectively improve the defecation situation of patients with post-stroke constipation of the liver-kidney deficiency type， and reduce their maximum tolerance threshold of the rectum.