Abstract： Objective： To observe the clinical efficacy of mindfulness decompression behavior combined with Chinese herbal medicine perfume therapy on negative emotions and sleep quality of patients with post-stroke sleep disorders （PSSD）. Methods：A total of 86 PSSD patients admitted to the Brain Disease Rehabilitation Department 3 of Fujian Rehabilitation Hospital from March 2021 to June 2022 were selected and divided into the control group and the trial group， with 43 patients in each group， using convenient sampling method. The control group received routine treatment， rehabilitation training， and nursing care， while the trial group received mindfulness decompression behavior intervention combined with Chinese herbal medicine perfume therapy on the basis of the control group. Both groups were intervened with six weeks. The scores of the Self-Rating Depression Scale （SDS）， Self-Rating Anxiety Scale （SAS），Pittsburgh Sleep Quality Index （PSQI），and National Institute of Health Stroke Scale （NIHSS） before and after the intervention as well as the clinical effects in the two groups were compared. Results：After intervention， the total effective rate was 81.40%（ 35/43） in the trial group，and 44.19%（ 19/43） in the control group，the difference being significant（ P＜0.05）. Before intervention，there was no significant difference in SDS and SAS scores between the two groups （P＞0.05）； after intervention， the SDS and SAS scores in the trial group were lower than those in the control group （P＜0.05）. Before intervention，there was no significant difference in the item-scores and total scores of PSQI in the two groups （P＞0.05）；after intervention，the PSQI scores of sleep onset time，sleep duration，quality， efficiency，sleep disorders，and daytime dysfunction and the total score in the trial group were lower than those in the control group （P＜0.05）. Before intervention， there was no significant difference in NIHSS scores between the two groups（ P＞0.05）；after intervention，the NIHSS score in the trial group was significantly lower than that in the control group （P＜0.05）. Conclusion： Mindfulness decompression behavior combined with aromatherapy can improve negative emotions and neurological deficits in PSSD patients，and enhance sleep quality.