Abstract: Objective: To observe the clinical effect of acupuncture at the sphenopalatine ganglion in the treatment of allergic rhinitis( AR). Methods:A total of 49 AR patients who received acupuncture at the sphenopalatine ganglion and conventional western medicine treatment at Lishui Central Hospital from September 2021 to October 2023 were included in the acupuncture group,and another 49 AR patients who received western medicine treatment at the same hospital during the same period were selected in a 1∶1 ratio as the conventional group. Clinical effects in the two groups were compared. The Total Nasal Symptoms Score (TNSS), the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), the Visual Analogue Scale (VAS) for pain evaluation, and complications were compared between the two groups before and after treatment. Results: The total effective rate in the acupuncture group was 97.96% (48/49),which was higher than that of 85.71% (42/49) in the conventional group,with the difference being significant (P<0.05). After two,three,four and eight weeks of treatment,the TNSS scores in the two groups were decreased when compared with those before treatment (P<0.05),and the TNSS scores in the acupuncture group were lower than those in the conventional group at four and eight weeks of treatment (P<0.05). After two,three,four,and eight weeks of treatment, the RQLQ scores in the two groups were declined when compared with those before treatment (P<0.05);however,there was no significant difference in RQLQ scores between the two groups at two and three weeks of treatment (P>0.05); the RQLQ scores in the acupuncture group were lower than those in the conventional group at four and eight weeks of treatment (P<0.05). After two, three, four weeks of treatment, both groups showed a decrease in VAS scores when compared with those before treatment (P<0.05), but there was no significant difference in pain VAS scores between the two groups at the three time points (P>0.05);after eight weeks of treatment,the VAS scores in the two groups were decreased compared to those before treatment (P<0.05),and the VAS scores in the acupuncture group were lower than those in the conventional group (P<0.05). After treatment,there was no significant difference in the incidence of four complications, including nausea, swelling and bruising of the lower eyelid, numbness of the upper jaw, and burning sensation of the nose, between the two groups (P>0.05). Conclusion:Acupuncture at the sphenopalatine ganglion is an auxiliary method to enhance the curative effects in the treatment of AR,which is beneficial for alleviating symptoms such as runny nose and nasal congestion,reducing pain, and improving quality of life,with good safety.