Abstract： Through a comprehensive summary encompassing literature review， academic theories， and clinical applications，it has been discovered that the etiology and pathogenesis of the toxicity syndrome （externally-contracted diseases and rheumatic diseases） are related to toxic pathogens. These can be categorized into eight types：wind toxin， cold toxin， dampness toxin， heat toxin， dryness toxin， phlegm toxin， blood stasis toxin， and deficiency toxin. In clinical practice， the counteracting toxin therapy can be employed for syndrome differentiation and treatment. By integrating these two concepts， a theoretical system of toxin therapy centered on Chinese medicine syndrome differentiation and treatment has been established，which has been applied in the clinical treatment of over 30 diseases. This system has been proven to have advantages such as definite efficacy and minimal side effects，revealing that the theoretical system of syndrome differentiation and treatment in Chinese medicine toxin therapy possesses significant academic value and clinical significance.