Abstract： Objective： The pathogenesis of ovarian function decline is mainly related to endocrine disorders， inflammatory damage， free radicals， antioxidant systems， mitochondrial function， abnormalities in telomere and telomerase， apoptosis and autophagy caused by hypothalamic-pituitary-ovarian axis imbalance. Chinese medicinals have a significant curative effect in the prevention and treatment of ovarian function decline. In recent years，there have been some achievements in the basic research on the active ingredients of Chinese medicinals in alleviating ovarian function decline. In this paper，the related research on the active ingredients of Chinese medicinals for ovarian function decline by in recent years is reviewed， and its mechanism is summarized from the aspects of regulating endocrine system，reducing inflammatory response，alleviating oxidative stress，and improving mitochondrial function，telomere homeostasis， anti-cell autophagy and apoptosis， which can provide a strong theoretical basis for subsequent clinical research and a reference for the development of drugs to prevent and treat ovarian function decline.