Abstract： Objective： To explore the potential action mechanism of Mongolian medicine Wuwei Shaji Powder （WWSJP） in treating chronic obstructive pulmonary disease （COPD） by using network pharmacology and molecular docking techniques. Methods： Potential active components and their targets of WWSJP were screened through TCMSP and SwissTargetPrediction databases. COPD-related targets were retrieved from GeneCards， OMIM， and DisGeNet databases. A Venn diagram was used to identify common targets between the medicine and the disease， and the STRING platform and Cytoscape 3.9.0 software were utilized to construct a protein-protein interaction （PPI） network and a Chinese medicine-component-target network；GO enrichment analysis and KEGG pathway enrichment analysis of the intersecting targets were performed using the DAVID database to identify key signaling pathways involved in WWSJP's treatment of COPD；core target protein structures were obtained from the PDB database，and molecular docking techniques were used to predict the binding affinity between major active components and core target proteins. Results：A total of 124 active components and 936 potential targets of WWSJP were identified，along with 816 COPDrelated targets. A total of 103 intersecting targets between the medicine and the disease were identified， mainly involving PI3K-AKT， AGE-RAGE， JAK-STAT， and MAPK signaling pathways. Molecular docking results showed that the main active components of WWSJP had strong binding abilities with VEGFA，IL-6，EGFR，PIK3CA，and JAK2，with quercetin showing the strongest binding affinity with EGFR. Conclusion：This study suggests that WWSJP can exert its therapeutic effects on COPD through multiple active components such as quercetin， kaempferol， stigmasterol， isorhamnetin， and 7-acetoxy-2-methylisoflavone. These components target VEGFA， IL-6， EGFR， PIK3CA， and JAK2， and regulate multiple signaling pathways including PI3K-AKT， AGE-RAGE， JAK-STAT， and MAPK，thereby inhibiting inflammatory reactions，oxidative stress，and apoptosis processes associated with COPD.