Abstract：Objective：To analyze the syndrome differentiation and medication rules in the treatment of seborrheic alopecia with Chinese medicine at the Second Affiliated Hospital of Guangzhou University of Chinese Medicine by data mining techniques. Methods：Collected internal Chinese medicine prescriptions for the treatment of seborrheic alopecia from the dermatology department of the Second Affiliated Hospital of Guangzhou University of Chinese Medicine， spanning from September 1， 2023， to November 30， 2023. Used Excel 2016 and the Ancient and Modern Medical Case Cloud Platform software and applied data mining techniques such as statistical analysis，association rules analysis， and complex network analysis to identify medication rules in the Chinese medicine treatment of seborrheic alopecia. Results： A total of 371 prescriptions were included， involving 347 different Chinese medicinals. The top 10 most frequently used Chinese medicinals were Poria， Dioscoreae Rhizoma， Chinese pine leaf， Glycyrrhizae Radix et Rhizoma， Ligustri Lucidi Fructus， Cuscutae Semen， Salviae Miltiorrhizae Radix et Rhizoma， Ecliptae Herba， Taraxaci Herba，Rehmanniae Radix etc. The natures of the herbs were mainly neutral；the flavors were mostly sweet， bitter， and acrid； they primarily entered the spleen， liver， and kidney meridians. High-frequency system cluster analysis identified four groups of Chinese medicinals， namely C1： Dioscoreae Rhizoma， Glycyrrhizae Radix et Rhizoma， and Cuscutae Semen； C2： Poria， Chinese pine leaf， Salviae Miltiorrhizae Radix et Rhizoma， Taraxaci Herba，Rehmanniae Radix，Ligustri Lucidi Fructus，and Ecliptae Herba. C2 can be further divided into C3 and C4， that is， C3： Poria and Chinese pine leaf； C4： Salviae Miltiorrhizae Radix et Rhizoma， Taraxaci Herba， Rehmanniae Radix， Ligustri Lucidi Fructus， and Ecliptae Herba. Association analysis revealed common herb combinations such as Ecliptae Herba-Ligustri Lucidi Fructus， Chinese pine leaf-Poria， Rehmanniae Radix-Ligustri Lucidi Fructus， Glycyrrhizae Radix et Rhizoma-Poria， and Salviae Miltiorrhizae Radix et Rhizoma-Poria. Complex network analysis identified five groups of traditional Chinese medicine syndromes and their core prescriptions：For liver and kidney insufficiency syndrome，commonly used herbs include Ligustri Lucidi Fructus，Ecliptae Herba，Chinese pine leaf，Poria，Dioscoreae Rhizoma，Cuscutae Semen，Taraxaci Herba，Salviae Miltiorrhizae Radix et Rhizoma， Rehmanniae Radix Praeparata， etc. For liver and kidney yin deficiency syndrome， commonly used herbs include Ligustri Lucidi Fructus，Ecliptae Herba，Alismatis Rhizoma，Poria，Dioscoreae Rhizoma，Rehmanniae Radix，etc. For spleen and kidney insecurity syndrome， commonly used herbs include Nelumbinis Semen， Atractylodis Macrocephalae Rhizoma， Poria， Dioscoreae Rhizoma， Cuscutae Semen， Glycyrrhizae Radix et Rhizoma， Chinese pine leaf， etc. For yin deficiency resulting in vigorous fire syndrome， commonly used herbs include Ligustri Lucidi Fructus， Poria， Cuscutae Semen， Taraxaci Herba， Ecliptae Herba， Rehmanniae Radix， Glycyrrhizae Radix et Rhizoma， etc. For spleen deficiency with damp-heat syndrome， commonly used herbs include Poria， Platycladi Cacumen， and Taraxaci Herba. Conclusion： At the second Affiliated Hospital of Guangzhou University of Chinese medicine， the primary treatment methods for seborrheic alopecia in Chinese medicine include supplementing and boosting the liver and kidney，nourishing yin and clearing heat，and strengthening the spleen and dispelling dampness. Commonly used basic prescriptions include Erzhi Pills， Qibao Meiran Granules， Liuwei Dihuang Decoction， and Shenling Baizhu Powder，which are modified as needed.